PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Achn380101
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; Ericales; Actinidiaceae; Actinidia
Family E2F/DP
Protein Properties Length: 386aa    MW: 43745.4 Da    PI: 9.569
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Achn380101genomeIKGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP75.36.1e-242085171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rkeksL+ll+++fl+l+ k   +++ l+e+a++L   +v  +rRRiYDi+NVLe+++++++++kn+++wkg
  Achn380101 20 RKEKSLGLLCTNFLSLYDKDGVETIGLDEAATRL---EV--ERRRIYDIVNVLESVGVLARMAKNRYSWKG 85
                79*****************999************...99..****************************98 PP

2E2F_TDP74.21.4e-23152232171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 rkeksL+lltq+f+kl+ +s+ + ++l+++ak L+ +       ++k+RR+YDi NVL+++n iek     ++k+++rw g
  Achn380101 152 RKEKSLGLLTQNFIKLFLCSNVELISLDDAAKILLGDahdpsIRRTKVRRLYDISNVLSSMNFIEKihhpeTRKPAFRWLG 232
                 79***************************************97789*********************************87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.7E-261886IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-272085IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.22E-152083IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023198.4E-202185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.7E-23148233IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.8E-31152232IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.1E-18153232IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.45E-11154233IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MAMPSSEPKE SGSRHFPYCR KEKSLGLLCT NFLSLYDKDG VETIGLDEAA TRLEVERRRI  60
YDIVNVLESV GVLARMAKNR YSWKGFRGIP QALQDLKEEG LRENYSTFEV NAKVSDDDED  120
EKVSISIASS QDDKINRSSV SSFSKASKTN NRKEKSLGLL TQNFIKLFLC SNVELISLDD  180
AAKILLGDAH DPSIRRTKVR RLYDISNVLS SMNFIEKIHH PETRKPAFRW LGIREKSENG  240
SENAFVLKES KKRVFGTEIT NTSFKRSKAL LPKDGYSNQM SKTQLQAHVK CEPMGNEVHK  300
SNLQQDSRQS SKGYRFGPFA PVSVSRAGAA EKNNAKQVHD WENLAATYRP EYHNQALRDL  360
FDHYVEAWKS WHSEVAGKNP IQLMS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-43202244228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028051660.10.0E2F transcription factor-like E2FE isoform X4
SwissprotQ8LSZ41e-124E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2R6QGS30.0A0A2R6QGS3_ACTCH; E2F transcription factor-like
STRINGXP_009607525.11e-170(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-124DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]