PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Achn300901

Organism

Actinidia chinensis

Taxonomic ID

3625

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; Ericales; Actinidiaceae; Actinidia

Family

E2F/DP

Protein Properties

Length: 378aa MW: 42076.2 Da PI: 4.8831

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Achn300901	genome	IKGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	76.5	2.6e-24	118	176	7	70
E2F_TDP 7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 +llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wk Achn300901 118 GLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWK 176 79************************...99..**************************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01372	4.7E-27	112	177	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.0E-21	118	176	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	3.4E-24	118	176	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.97E-15	118	175	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF144074	2.62E-31	173	277	No hit	No description
Pfam	PF16421	8.2E-32	178	275	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	2.82E-45	178	277	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 378 aa Download sequence Send to blast
MSASGAPNQQ QPLLKHQLPF AAAKPPFGDY HHFSASSVDH RQKQPEGIVV KSPQLKRKSV 60 KAEFEAESSE CNPSTGYAET LSSPFQTPVS GKGGKTQKAP NGAKSNRSGS QTPAAVVGLL 120 TKKFINLIKH AEDGILDLNK AADTLEVQKR RIYDITNVLE GIGLIEKKLK NRIQWKYAEV 180 ENLSIEEHRL DDKIREMQEK LRELSENKNN EKWLFVTEDD IKSLPCFQNE TLIAIKAPHG 240 TTLEVPDPDE AVDYPQRRYR IVLRSTMGPV DVYLVSQFEE KFEESNAVEA PPGIPSTSGF 300 NENPAVPMAI EETTGNELGM QGQEDQRLCT DTNASQDFVS GIMKIVPEVD SDADYWLLSD 360 ADVSITDMWR TERILYS*

Sequence ? help Back to Top

Protein Sequence Length: 378 aa Download sequence Send to blast

MSASGAPNQQ QPLLKHQLPF AAAKPPFGDY HHFSASSVDH RQKQPEGIVV KSPQLKRKSV  60
KAEFEAESSE CNPSTGYAET LSSPFQTPVS GKGGKTQKAP NGAKSNRSGS QTPAAVVGLL  120
TKKFINLIKH AEDGILDLNK AADTLEVQKR RIYDITNVLE GIGLIEKKLK NRIQWKYAEV  180
ENLSIEEHRL DDKIREMQEK LRELSENKNN EKWLFVTEDD IKSLPCFQNE TLIAIKAPHG  240
TTLEVPDPDE AVDYPQRRYR IVLRSTMGPV DVYLVSQFEE KFEESNAVEA PPGIPSTSGF  300
NENPAVPMAI EETTGNELGM QGQEDQRLCT DTNASQDFVS GIMKIVPEVD SDADYWLLSD  360
ADVSITDMWR TERILYS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-22	117	176	12	72	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_028060630.1	0.0	transcription factor E2FB-like
Refseq	XP_028086786.1	0.0	transcription factor E2FB-like
Refseq	XP_028105353.1	0.0	transcription factor E2FB-like isoform X1
Swissprot	Q9FV71	1e-123	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A2R6PEM3	0.0	A0A2R6PEM3_ACTCH; Transcription factor E2FB like
STRING	cassava4.1_007936m	0.0	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-125	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]