PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Achn198021

Organism

Actinidia chinensis

Taxonomic ID

3625

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; Ericales; Actinidiaceae; Actinidia

Family

E2F/DP

Protein Properties

Length: 264aa MW: 29685.3 Da PI: 9.5217

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Achn198021	genome	IKGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	78.5	6.3e-25	53	133	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 rkeksL+lltq+f+kl+ +s+e ++l+e+ak+L+ + ++k+RR+YDi+NV+++++liek ++k+++rw g Achn198021 53 RKEKSLGLLTQNFIKLFLSSKEALISLDEAAKALLGDlrdptALRTKVRRLYDIANVFSSMDLIEKthhpeSRKPAFRWLG 133 79**************************************9999****************9999999****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.1E-5	15	50	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	4.1E-24	51	135	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.9E-33	53	133	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.7E-20	54	133	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.63E-12	55	134	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 264 aa Download sequence Send to blast
MSSPRESDPQ NPNYYNRKDK SLGVLCSNFL KLYDRDGVDS IGLDDAANRL DNRKEKSLGL 60 LTQNFIKLFL SSKEALISLD EAAKALLGDL RDPTALRTKV RRLYDIANVF SSMDLIEKTH 120 HPESRKPAFR WLGLKGSSKN GPATALDLKE SKKRVFGTDI TNTLPKKYKA DSSLEWNSNQ 180 KEQQGKHSSK DFVFGPFTPA KVAEGGDSEN KNVSRAQDLE DLASSYRPQY RNQALSNLFS 240 HYVAAWKSWY VEADETKQIQ EVS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	6e-17	34	125	133	228	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_028059824.1	1e-112	E2F transcription factor-like E2FF isoform X1
Swissprot	Q8LSZ4	7e-60	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A2R6RK64	1e-148	A0A2R6RK64_ACTCH; E2F transcription factor-like
STRING	VIT_14s0066g02370.t01	3e-92	(Vitis vinifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA2522	24	57

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	3e-62	DP-E2F-like 1

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]