PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AA8G00251

Organism

Aethionema arabicum

Taxonomic ID

228871

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema

Family

E2F/DP

Protein Properties

Length: 514aa MW: 57129 Da PI: 6.0746

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AA8G00251	genome	VEGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	77.6	1.2e-24	154	213	7	71
E2F_TDP 7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn+i+wkg AA8G00251 154 SLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIQWKG 213 589***********************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01372	1.9E-28	148	213	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	5.0E-22	154	213	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	5.7E-25	154	215	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.36E-15	154	211	IPR011991	Winged helix-turn-helix DNA-binding domain
CDD	cd14660	2.27E-40	224	354	No hit	No description
Pfam	PF16421	3.9E-25	272	352	IPR032198	E2F transcription factor, CC-MB domain
SuperFamily	SSF144074	6.8E-24	273	354	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 514 aa Download sequence Send to blast
MSKSQQEPHQ HPSMKRQHHP SMSSMKPPLV APGDYHRFNT AETRGGGAAA DQFSEAIVIK 60 SDLKRKTDLA NQRTEPNELN TAVLQTPVGG KGGKTKKSSR SAKSSKSGAH ASGSNAGSPG 120 SNFVQAGTCR YDSSLGNNLL DKLMFEEKYF WIISLLTKKF INLIKQAEDG ILDLNKAADT 180 LEVQKRRIYD ITNVLEGIGL IEKTLKNRIQ WKGLDVSKPG ETVESIANLQ DETQNLTAEE 240 AKLDYQIRYP CGSLSFTYLL YVYLPDNQLG CSELQERLTS LSEDENNKKF LFVTEDDIKS 300 LPCFQNKTLI AVKAPHGTTL EVPDPDEAGG YPQRRYRIIL RSTMGPIDVY LVSQFEEKFE 360 ELPHANEPST SGFHENQEVA THMEEDSTDK NMETPDLDDT QRVFSDIDSR DFVDGIMKIV 420 PPVLDVSPNF FYKITASPLI NILKSKPAMS ASQTCGLMNL NSSFTLYHHS AESNWKQTVS 480 FNQDPGPSNV AQKQQPQTPS SLNADHSTVR STGN

Sequence ? help Back to Top

Protein Sequence Length: 514 aa Download sequence Send to blast

MSKSQQEPHQ HPSMKRQHHP SMSSMKPPLV APGDYHRFNT AETRGGGAAA DQFSEAIVIK  60
SDLKRKTDLA NQRTEPNELN TAVLQTPVGG KGGKTKKSSR SAKSSKSGAH ASGSNAGSPG  120
SNFVQAGTCR YDSSLGNNLL DKLMFEEKYF WIISLLTKKF INLIKQAEDG ILDLNKAADT  180
LEVQKRRIYD ITNVLEGIGL IEKTLKNRIQ WKGLDVSKPG ETVESIANLQ DETQNLTAEE  240
AKLDYQIRYP CGSLSFTYLL YVYLPDNQLG CSELQERLTS LSEDENNKKF LFVTEDDIKS  300
LPCFQNKTLI AVKAPHGTTL EVPDPDEAGG YPQRRYRIIL RSTMGPIDVY LVSQFEEKFE  360
ELPHANEPST SGFHENQEVA THMEEDSTDK NMETPDLDDT QRVFSDIDSR DFVDGIMKIV  420
PPVLDVSPNF FYKITASPLI NILKSKPAMS ASQTCGLMNL NSSFTLYHHS AESNWKQTVS  480
FNQDPGPSNV AQKQQPQTPS SLNADHSTVR STGN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	9e-22	153	214	12	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AA8G00251

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF242580	1e-111	AF242580.1 Arabidopsis thaliana E2F transcription factor-1 E2F1 mRNA, complete cds.
GenBank	AJ294533	1e-111	AJ294533.1 Arabidopsis thaliana mRNA for E2F-related protein (e2Fb gene).
GenBank	AY136479	1e-111	AY136479.1 Arabidopsis thaliana expressed protein (At5g22220) mRNA, complete cds.
GenBank	BT006610	1e-111	BT006610.1 Arabidopsis thaliana At5g22220 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006400728.2	0.0	transcription factor E2FB isoform X1
Swissprot	Q9FV71	0.0	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A1J3K7H5	0.0	A0A1J3K7H5_NOCCA; Transcription factor E2FB
STRING	Bostr.26527s0055.1.p	0.0	(Boechera stricta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	0.0	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]