PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AA102G00020

Organism

Aethionema arabicum

Taxonomic ID

228871

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema

Family

G2-like

Protein Properties

Length: 384aa MW: 42629.2 Da PI: 6.3973

Description

G2-like family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AA102G00020	genome	VEGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	107.7	6.1e-34	203	257	1	55
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 k+r+rWtpeLHe+Fveav++LGGse+AtPk +l++mkv+gLt++hvkSHLQkYR+ AA102G00020 203 KARMRWTPELHEAFVEAVNHLGGSERATPKGVLKIMKVEGLTIYHVKSHLQKYRT 257 68****************************************************8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	11.756	200	260	IPR017930	Myb domain
Gene3D	G3DSA:1.10.10.60	3.8E-31	201	259	IPR009057	Homeodomain-like
SuperFamily	SSF46689	2.15E-17	202	257	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	3.1E-25	203	257	IPR006447	Myb domain, plants
Pfam	PF00249	2.2E-9	205	256	IPR001005	SANT/Myb domain
Pfam	PF14379	2.1E-23	290	333	IPR025756	MYB-CC type transcription factor, LHEQLE-containing domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0007623	Biological Process	circadian rhythm
GO:0016036	Biological Process	cellular response to phosphate starvation
GO:0055063	Biological Process	sulfate ion homeostasis
GO:0071486	Biological Process	cellular response to high light intensity
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 384 aa Download sequence Send to blast
MEARPVQRSD SRELSNNLAR TSSMPKTPAE NTRHLSQHDY HMLPTNGGSV GHICTSSSTS 60 FSSNLQYSPV VLHEKHTGSS SSAPFISQTS SNNSSWCPDP LPPGFLDFPE NSAIQNSHIE 120 GGSRIGDPNW QEWADHLITD EDPLISTNWN DLLLDTSSIN PDSKDPKSMQ LVAQQQPSPS 180 VELRPVSTVS STSTNSNNNS TGKARMRWTP ELHEAFVEAV NHLGGSERAT PKGVLKIMKV 240 EGLTIYHVKS HLQKYRTARY RPEPSEGSSE QKLTPLEHIT SLDLKSGIGI TEALRLQMEV 300 QKQLHAQLEI QRNLQLRIEE QGKYLQMMFE KQTSGLTKGT TSDSPPKSEQ QDDKIVDTDA 360 LRTEETIKSS QDPQSPSPKR SKID

Sequence ? help Back to Top

Protein Sequence Length: 384 aa Download sequence Send to blast

MEARPVQRSD SRELSNNLAR TSSMPKTPAE NTRHLSQHDY HMLPTNGGSV GHICTSSSTS  60
FSSNLQYSPV VLHEKHTGSS SSAPFISQTS SNNSSWCPDP LPPGFLDFPE NSAIQNSHIE  120
GGSRIGDPNW QEWADHLITD EDPLISTNWN DLLLDTSSIN PDSKDPKSMQ LVAQQQPSPS  180
VELRPVSTVS STSTNSNNNS TGKARMRWTP ELHEAFVEAV NHLGGSERAT PKGVLKIMKV  240
EGLTIYHVKS HLQKYRTARY RPEPSEGSSE QKLTPLEHIT SLDLKSGIGI TEALRLQMEV  300
QKQLHAQLEI QRNLQLRIEE QGKYLQMMFE KQTSGLTKGT TSDSPPKSEQ QDDKIVDTDA  360
LRTEETIKSS QDPQSPSPKR SKID

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6j4k_A	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j4k_B	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_A	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_C	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_D	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_F	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_H	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_J	1e-34	202	261	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568). {ECO:0000269\|PubMed:11511543, ECO:0000269\|PubMed:17643101, ECO:0000269\|PubMed:17927693, ECO:0000269\|PubMed:20838596, ECO:0000269\|PubMed:21261953, ECO:0000269\|PubMed:21910737, ECO:0000269\|PubMed:23788639, ECO:0000269\|PubMed:24420568, ECO:0000269\|PubMed:24753539, ECO:0000269\|PubMed:25271326, ECO:0000269\|PubMed:25680792, ECO:0000269\|PubMed:26586833}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AA102G00020

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Only moderately up-regulated by Pi starvation. {ECO:0000269\|PubMed:11511543}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AJ310799	1e-137	AJ310799.1 Arabidopsis thaliana mRNA for phosphate starvation response regulator 1 (phr1 gene).
GenBank	AY081290	1e-137	AY081290.1 Arabidopsis thaliana putative protein (At4g28610) mRNA, complete cds.
GenBank	BT002187	1e-137	BT002187.1 Arabidopsis thaliana putative protein (At4g28610) mRNA, complete cds.
GenBank	JN009802	1e-137	JN009802.1 UNVERIFIED: Lupinus polyphyllus phosphate starvation response regulator-like mRNA, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023635659.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1
Refseq	XP_023635660.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1
Swissprot	Q94CL7	1e-166	PHR1_ARATH; Protein PHOSPHATE STARVATION RESPONSE 1
TrEMBL	E4MWS3	1e-173	E4MWS3_EUTHA; mRNA, clone: RTFL01-12-I21
TrEMBL	V4P4I0	1e-173	V4P4I0_EUTSA; Uncharacterized protein
STRING	Bostr.7867s0704.1.p	0.0	(Boechera stricta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM856	27	117

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G28610.1	1e-142	phosphate starvation response 1

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Matsui K,Togami J,Mason JG,Chandler SF,Tanaka Y Enhancement of phosphate absorption by garden plants by genetic engineering: a new tool for phytoremediation. Biomed Res Int, 2013. 2013: p. 182032 [PMID:23984322] Jost R, et al. Differentiating phosphate-dependent and phosphate-independent systemic phosphate-starvation response networks in Arabidopsis thaliana through the application of phosphite. J. Exp. Bot., 2015. 66(9): p. 2501-14 [PMID:25697796] Zhou Z, et al. SPX proteins regulate Pi homeostasis and signaling in different subcellular level. Plant Signal Behav, 2015. 10(9): p. e1061163 [PMID:26224365] Bonnot C, et al. A chemical genetic strategy identify the PHOSTIN, a synthetic molecule that triggers phosphate starvation responses in Arabidopsis thaliana. New Phytol., 2016. 209(1): p. 161-76 [PMID:26243630] Khan GA,Vogiatzaki E,Glauser G,Poirier Y Phosphate Deficiency Induces the Jasmonate Pathway and Enhances Resistance to Insect Herbivory. Plant Physiol., 2016. 171(1): p. 632-44 [PMID:27016448] Velasco VM, et al. Acclimation of the crucifer Eutrema salsugineum to phosphate limitation is associated with constitutively high expression of phosphate-starvation genes. Plant Cell Environ., 2016. 39(8): p. 1818-34 [PMID:27038434] Yong-Villalobos L, et al. Phosphate starvation induces DNA methylation in the vicinity of cis-acting elements known to regulate the expression of phosphate-responsive genes. Plant Signal Behav, 2016. 11(5): p. e1173300 [PMID:27185363] Li Y,Wu H,Fan H,Zhao T,Ling HQ Characterization of the AtSPX3 Promoter Elucidates its Complex Regulation in Response to Phosphorus Deficiency. Plant Cell Physiol., 2016. 57(8): p. 1767-78 [PMID:27382128] Zhang H,Huang L,Hong Y,Song F BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana. BMC Plant Biol., 2016. 16(1): p. 152 [PMID:27389008] Yuan J, et al. Systematic characterization of novel lncRNAs responding to phosphate starvation in Arabidopsis thaliana. BMC Genomics, 2016. 17: p. 655 [PMID:27538394] Linn J, et al. Root Cell-Specific Regulators of Phosphate-Dependent Growth. Plant Physiol., 2017. 174(3): p. 1969-1989 [PMID:28465462] Aleksza D,Horváth GV,Sándor G,Szabados L Proline Accumulation Is Regulated by Transcription Factors Associated with Phosphate Starvation. Plant Physiol., 2017. 175(1): p. 555-567 [PMID:28765275] Liu Y, et al. Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation of PHOSPHATE STARVATION RESPONSE1. Plant Cell, 2017. 29(9): p. 2269-2284 [PMID:28842534] Qi W,Manfield IW,Muench SP,Baker A AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution. Biochem. J., 2017. 474(21): p. 3675-3687 [PMID:28887383] Huang KL, et al. The ARF7 and ARF19 Transcription Factors Positively Regulate PHOSPHATE STARVATION RESPONSE1 in Arabidopsis Roots. Plant Physiol., 2018. 178(1): p. 413-427 [PMID:30026290] Jiang M, et al. Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1. FEBS J., 2019. [PMID:30974511]