PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK40611.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family TALE
Protein Properties Length: 385aa    MW: 43170.6 Da    PI: 6.8532
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK40611.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox28.91.9e-093113452155
                 HSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
    Homeobox  21 knrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                 k +yps++++  LA+++gL+++q+ +WF N+R ++
  KFK40611.1 311 KWPYPSEQQKLALAESTGLDQKQINNWFINQRKRH 345
                 569*****************************885 PP

2ELK414e-14265286122
         ELK   1 ELKhqLlrKYsgyLgsLkqEFs 22 
                 ELK qLlrKYsgyLgsLkqEF+
  KFK40611.1 265 ELKGQLLRKYSGYLGSLKQEFM 286
                 9********************8 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM012552.8E-19122166IPR005540KNOX1
PfamPF037909.5E-22124161IPR005540KNOX1
SMARTSM012561.2E-25173224IPR005541KNOX2
PfamPF037913.9E-20177222IPR005541KNOX2
PfamPF037896.5E-11265286IPR005539ELK domain
PROSITE profilePS5121311.174265285IPR005539ELK domain
SMARTSM011882.8E-8265286IPR005539ELK domain
PROSITE profilePS5007113.151285348IPR001356Homeobox domain
SuperFamilySSF466891.5E-19287363IPR009057Homeodomain-like
SMARTSM003895.3E-13287352IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.605.0E-28290350IPR009057Homeodomain-like
CDDcd000861.60E-12297349No hitNo description
PfamPF059203.4E-17305344IPR008422Homeobox KN domain
PROSITE patternPS000270323346IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009934Biological Processregulation of meristem structural organization
GO:0048440Biological Processcarpel development
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 385 aa     Download sequence    Send to blast
MEGGSNSTSC PMAFAGDNSD GPMCPMMMMM MPIMTSHQHH GHAHQHQQQQ HDGYAYQSHH  60
QQSSPFFLQS LAPPPPPRET KNKVASSSPS SCAPAYSLME IHHQNDALAG GINPCSSSSS  120
PASVKAKIMA HPHYHRLLAA YVNCQKVGAP PEVAARLEEA YSSAAAAAAS MGPTGCLGED  180
PGLDQFMEAY CEMLVKYEQE LSKPYKEAMV FLQRVECQFK SLSLSSPSSF SGYGEAAIDR  240
NNNGSSEEEV DMNNEFIDPQ AEDRELKGQL LRKYSGYLGS LKQEFMKKRK KGKLPKEARQ  300
QLLDWWSRHY KWPYPSEQQK LALAESTGLD QKQINNWFIN QRKRHWKPSE DMQFVVMDAT  360
HPHHYFMDNV LGNPFPIDHI SSTML
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1280289LKQEFMKKRK
2286290KKRKK
Functional Description ? help Back to Top
Source Description
UniProtRequired for shoot apical meristem (SAM) formation during embryogenesis. Negatively regulates ASYMMETRIC LEAVES1 (AS1) and ASYMMETRIC LEAVES2 (AS2 or LBD6). Probably binds to the DNA sequence 5'-TGAC-3'. Binds to RNA (By similarity). {ECO:0000250|UniProtKB:P24345, ECO:0000269|PubMed:10079219, ECO:0000269|PubMed:11934861}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK40611.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankATU323440.0U32344.1 Arabidopsis thaliana Shootmeristemless (STM) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001302988.10.0homeobox protein SHOOT MERISTEMLESS
SwissprotQ388740.0STM_ARATH; Homeobox protein SHOOT MERISTEMLESS
TrEMBLA0A087HEQ90.0A0A087HEQ9_ARAAL; Uncharacterized protein
STRINGA0A087HEQ90.0(Arabis alpina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM64732644
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G62360.10.0KNOX/ELK homeobox transcription factor
Publications ? help Back to Top
  1. Zhang XL,Yang ZP,Zhang J,Zhang LG
    Ectopic expression of BraYAB1-702, a member of YABBY gene family in Chinese cabbage, causes leaf curling, inhibition of development of shoot apical meristem and flowering stage delaying in Arabidopsis thaliana.
    Int J Mol Sci, 2013. 14(7): p. 14872-91
    [PMID:23863694]
  2. Liu C, et al.
    Phosphatidylserine synthase 1 is required for inflorescence meristem and organ development in Arabidopsis.
    J Integr Plant Biol, 2013. 55(8): p. 682-95
    [PMID:23931744]
  3. Simonini S,Kater MM
    Class I BASIC PENTACYSTEINE factors regulate HOMEOBOX genes involved in meristem size maintenance.
    J. Exp. Bot., 2014. 65(6): p. 1455-65
    [PMID:24482368]
  4. Scofield S,Dewitte W,Murray JA
    STM sustains stem cell function in the Arabidopsis shoot apical meristem and controls KNOX gene expression independently of the transcriptional repressor AS1.
    Plant Signal Behav, 2018.
    [PMID:24776954]
  5. Kamiuchi Y,Yamamoto K,Furutani M,Tasaka M,Aida M
    The CUC1 and CUC2 genes promote carpel margin meristem formation during Arabidopsis gynoecium development.
    Front Plant Sci, 2014. 5: p. 165
    [PMID:24817871]
  6. Chen C, et al.
    Transcriptome profiling reveals roles of meristem regulators and polarity genes during fruit trichome development in cucumber (Cucumis sativus L.).
    J. Exp. Bot., 2014. 65(17): p. 4943-58
    [PMID:24962999]
  7. Lee JE,Lampugnani ER,Bacic A,Golz JF
    SEUSS and SEUSS-LIKE 2 coordinate auxin distribution and KNOXI activity during embryogenesis.
    Plant J., 2014. 80(1): p. 122-35
    [PMID:25060324]
  8. Ckurshumova W,Berleth T
    Overcoming recalcitrance - Auxin response factor functions in plant regeneration.
    Plant Signal Behav, 2015. 10(7): p. e993293
    [PMID:26098229]
  9. Liang Z,Brown RC,Fletcher JC,Opsahl-Sorteberg HG
    Calpain-Mediated Positional Information Directs Cell Wall Orientation to Sustain Plant Stem Cell Activity, Growth and Development.
    Plant Cell Physiol., 2015. 56(9): p. 1855-66
    [PMID:26220906]
  10. Rast-Somssich MI, et al.
    Alternate wiring of a KNOXI genetic network underlies differences in leaf development of A. thaliana and C. hirsuta.
    Genes Dev., 2015. 29(22): p. 2391-404
    [PMID:26588991]
  11. Landrein B, et al.
    Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems.
    Elife, 2015. 4: p. e07811
    [PMID:26623515]
  12. Guzmán-López JA,Abraham-Juárez MJ,Lozano-Sotomayor P,de Folter S,Simpson J
    Arabidopsis thaliana gonidialess A/Zuotin related factors (GlsA/ZRF) are essential for maintenance of meristem integrity.
    Plant Mol. Biol., 2016. 91(1-2): p. 37-51
    [PMID:26826012]
  13. Shi B, et al.
    Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis.
    PLoS Genet., 2016. 12(7): p. e1006168
    [PMID:27398935]
  14. Lee HG,Choi YR,Seo PJ
    Increased STM expression is associated with drought tolerance in Arabidopsis.
    J. Plant Physiol., 2016. 201: p. 79-84
    [PMID:27448723]
  15. Balkunde R,Kitagawa M,Xu XM,Wang J,Jackson D
    SHOOT MERISTEMLESS trafficking controls axillary meristem formation, meristem size and organ boundaries in Arabidopsis.
    Plant J., 2017. 90(3): p. 435-446
    [PMID:28161901]
  16. Singh S, et al.
    Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components.
    Sci Rep, 2017. 7: p. 42450
    [PMID:28195159]
  17. Lee HG,Choi YR,Seo PJ
    Erratum to "Increased STM expression is associated with drought tolerance in Arabidopsis" [J. Plant Physiol. 201 (2016) 79-84].
    J. Plant Physiol., 2018. 228: p. 218
    [PMID:28456397]
  18. Xue T, et al.
    ARGONAUTE10 Inhibits In Vitro Shoot Regeneration Via Repression of miR165/166 in Arabidopsis thaliana.
    Plant Cell Physiol., 2017. 58(10): p. 1789-1800
    [PMID:29016889]
  19. Dolzblasz A, et al.
    Impairment of Meristem Proliferation in Plants Lacking the Mitochondrial Protease AtFTSH4.
    Int J Mol Sci, 2018.
    [PMID:29538317]
  20. Scofield S, et al.
    Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network.
    Development, 2018.
    [PMID:29650590]
  21. Liu L, et al.
    FTIP-Dependent STM Trafficking Regulates Shoot Meristem Development in Arabidopsis.
    Cell Rep, 2018. 23(6): p. 1879-1890
    [PMID:29742441]
  22. Chung Y, et al.
    Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS.
    Nat Commun, 2019. 10(1): p. 886
    [PMID:30792395]