PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

KFK35687.1

Organism

Arabis alpina

Taxonomic ID

50452

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis

Family

ERF

Protein Properties

Length: 319aa MW: 36057.1 Da PI: 5.0459

Description

ERF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
KFK35687.1	genome	MPIPBR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	64.4	2.3e-20	113	161	3	55
AP2 3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 y+G+r+++ +g+W+AeIrdp+e +r++lg+f taeeAa+a++aa+++++g KFK35687.1 113 YRGIRQRP-WGKWAAEIRDPKE---GARIWLGTFKTAEEAARAYDAAARRIRG 161 9*****.******966...3***********************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51032	24.289	112	169	IPR001471	AP2/ERF domain
SuperFamily	SSF54171	3.4E-22	112	170	IPR016177	DNA-binding domain
Gene3D	G3DSA:3.30.730.10	8.2E-33	112	171	IPR001471	AP2/ERF domain
SMART	SM00380	6.1E-38	112	175	IPR001471	AP2/ERF domain
CDD	cd00018	3.32E-18	113	170	No hit	No description
Pfam	PF00847	4.7E-13	113	161	IPR001471	AP2/ERF domain
PRINTS	PR00367	9.2E-12	113	124	IPR001471	AP2/ERF domain
PRINTS	PR00367	9.2E-12	135	151	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0070483	Biological Process	detection of hypoxia
GO:0005634	Cellular Component	nucleus
GO:0005886	Cellular Component	plasma membrane
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 319 aa Download sequence Send to blast
MCGGAIISDF IPPPRSRRVT NEFIWPDLRK NVKGLKKKSF FDLDVDFEAD FQGFKDDSFD 60 SDDDDDVFAD LKPFVFTTPT PKPIKDSGLG KKVVDYKGGV EKESVKRKRK NEYRGIRQRP 120 WGKWAAEIRD PKEGARIWLG TFKTAEEAAR AYDAAARRIR GSKAKVNFPE ENPIVVSQKR 180 PAKTATQKPN PALVPNVESM CFMEEKHQVN NNNNNQFVDV GGNGYNQYFS SDQGSNSFDC 240 SEFGWNDQAP ITPEISSALF VEEANPAKKL KSMDFQTPYN NNTEWDSSLD FFNVDAVATQ 300 DNDADSMELW IHSMIGGNF

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1gcc_A	2e-23	113	169	3	60	ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in the activation of hypoxic gene expression and in ethylene response. Partially redundant with RAP2-2. Acts as a downstream regulator in the ethylene signaling pathway. {ECO:0000269\|PubMed:22020282, ECO:0000269\|PubMed:22530619}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00204	DAP	Transfer from AT1G53910	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	KFK35687.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by hypoxia but not by ethylene. {ECO:0000269\|PubMed:22020282}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC009324	2e-31	AC009324.2 Arabidopsis thaliana chromosome I BAC T18A20 genomic sequence, complete sequence.
GenBank	AK316980	2e-31	AK316980.1 Arabidopsis thaliana AT1G53910 mRNA, complete cds, clone: RAFL16-70-F02.
GenBank	AK353211	2e-31	AK353211.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-22-M23.
GenBank	AY037260	2e-31	AY037260.1 Arabidopsis thaliana At1g53910/T18A20_14 mRNA, complete cds.
GenBank	AY057545	2e-31	AY057545.1 Arabidopsis thaliana At1g53910/T18A20_14 mRNA, complete cds.
GenBank	AY088204	2e-31	AY088204.1 Arabidopsis thaliana clone 42960 mRNA, complete sequence.
GenBank	AY113051	2e-31	AY113051.1 Arabidopsis thaliana At1g53910/T18A20_14 mRNA, complete cds.
GenBank	CP002684	2e-31	CP002684.1 Arabidopsis thaliana chromosome 1 sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006392736.1	1e-143	ethylene-responsive transcription factor RAP2-12
Refseq	XP_006392737.1	1e-143	ethylene-responsive transcription factor RAP2-12
Swissprot	Q9SSA8	1e-142	RA212_ARATH; Ethylene-responsive transcription factor RAP2-12
TrEMBL	A0A087H0N5	0.0	A0A087H0N5_ARAAL; Uncharacterized protein
STRING	A0A087H0N5	0.0	(Arabis alpina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM10	28	1650

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G53910.2	1e-124	related to AP2 12

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Kosmacz M, et al. The stability and nuclear localization of the transcription factor RAP2.12 are dynamically regulated by oxygen concentration. Plant Cell Environ., 2015. 38(6): p. 1094-103 [PMID:25438831] Bui LT,Giuntoli B,Kosmacz M,Parlanti S,Licausi F Constitutively expressed ERF-VII transcription factors redundantly activate the core anaerobic response in Arabidopsis thaliana. Plant Sci., 2015. 236: p. 37-43 [PMID:26025519] Gasch P, et al. Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis. Plant Cell, 2016. 28(1): p. 160-80 [PMID:26668304] Gonzali S, et al. Universal stress protein HRU1 mediates ROS homeostasis under anoxia. Nat Plants, 2015. 1: p. 15151 [PMID:27251529] Paul MV, et al. Oxygen Sensing via the Ethylene Response Transcription Factor RAP2.12 Affects Plant Metabolism and Performance under Both Normoxia and Hypoxia. Plant Physiol., 2016. 172(1): p. 141-53 [PMID:27372243] Shahzad Z, et al. A Potassium-Dependent Oxygen Sensing Pathway Regulates Plant Root Hydraulics. Cell, 2016. 167(1): p. 87-98.e14 [PMID:27641502] Yao Y, et al. ETHYLENE RESPONSE FACTOR 74 (ERF74) plays an essential role in controlling a respiratory burst oxidase homolog D (RbohD)-dependent mechanism in response to different stresses in Arabidopsis. New Phytol., 2017. 213(4): p. 1667-1681 [PMID:28164334] Giuntoli B,Licausi F,van Veen H,Perata P Functional Balancing of the Hypoxia Regulators RAP2.12 and HRA1 Takes Place in vivo in Arabidopsis thaliana Plants. Front Plant Sci, 2017. 8: p. 591 [PMID:28487707] Yao Y,Chen X,Wu AM ERF-VII members exhibit synergistic and separate roles in Arabidopsis. Plant Signal Behav, 2017. 12(6): p. e1329073 [PMID:28537474] Eysholdt-Derzsó E,Sauter M Root Bending Is Antagonistically Affected by Hypoxia and ERF-Mediated Transcription via Auxin Signaling. Plant Physiol., 2017. 175(1): p. 412-423 [PMID:28698356] Giuntoli B, et al. Age-dependent regulation of ERF-VII transcription factor activity in Arabidopsis thaliana. Plant Cell Environ., 2017. 40(10): p. 2333-2346 [PMID:28741696]