PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK34110.1
Organism
Arabis alpina
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family E2F/DP
Protein Properties Length: 384aa    MW: 43410.4 Da    PI: 7.4133
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK34110.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.79.6e-241984171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rk+ksL+ll+++fl+l++++  ++v l+++a++L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  KFK34110.1 19 RKQKSLGLLCTNFLALYNREGIETVGLDDAATKL---GV--ERRRIYDIVNVLESVGVLTRRAKNQYTWKG 84
                79*****************999************...**..****************************98 PP
2E2F_TDP79.92.3e-25152232171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 r+eksL+lltq+f+kl+ +se++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  KFK34110.1 152 RREKSLGLLTQNFIKLFVCSEARIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 232
                 689**************************************999************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-261586IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.66E-161882IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.0E-291984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.4E-212084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.2E-23149233IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-32152232IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.2E-20154232IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.74E-14154233IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 384 aa     Download sequence    Send to blast
MALSSPPESS SSLHHSYSRK QKSLGLLCTN FLALYNREGI ETVGLDDAAT KLGVERRRIY  60
DIVNVLESVG VLTRRAKNQY TWKGFDAIPA ALKELQEEGA KDTFHRFYTN ENVKVSDDED  120
DDEESSQPSS QTDSSKAGSL PQTSDSSKID NRREKSLGLL TQNFIKLFVC SEARIISLDE  180
AAKLLLGDAH NTSIMRTKVR RLYDIANVLS SMNLIEKTHT LDSRKPAFKW LGYNGEPTFT  240
FTLSNDLMQA ESRKRVFGTD ITNVNVKRSK THENAASERT LKMKKHAVEE SSCNKSFDTT  300
HESRHGSRGY QFGPFAPATG TYPTATLDDN SRRAFDVENL VSDYRPSYQN QVLKDLFAHY  360
MDAWKEWYSE VTKKDPLPNT SPHH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-41182243228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK34110.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3531970.0AK353197.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-26-N13.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006404291.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A087GW580.0A0A087GW58_ARAAL; Uncharacterized protein
STRINGA0A087GW570.0(Arabis alpina)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]