PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK31432.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family bHLH
Protein Properties Length: 585aa    MW: 64477.2 Da    PI: 4.8533
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK31432.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.69.3e-13416461454
                 HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
         HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                 +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  KFK31432.1 416 NHVEAERQRREKLNQKFYSLRAVVPNV-----SKMDKASLLGDAISYINEL 461
                 799***********************6.....5***************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142152.4E-5452238IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.142412461IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.71E-14415466No hitNo description
SuperFamilySSF474591.57E-17415477IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.3E-10416461IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.106.9E-18416478IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.4E-16418467IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006952Biological Processdefense response
GO:0009718Biological Processanthocyanin-containing compound biosynthetic process
GO:0009753Biological Processresponse to jasmonic acid
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043425Molecular FunctionbHLH transcription factor binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 585 aa     Download sequence    Send to blast
MNDYFINHST ATTTDDDTST AMEPFIGTTN HHHSSIFPPP PPPPPNFNED TLQQRLQALI  60
ESASENWLYA IFWQISHDFN SSTGDNTVIL GWGDGYYKGE EDKEKKKKTK SESNPLEQEH  120
RKRVIRELNS LISGGVGVSD EANDEEVTDT EWFFLVSMTQ SFVNGVGLPG ESYQNSRVIW  180
LSGSGSLTGS GCERAGQGQV YGLQTMVCIA TENGVVELGS SDVIDQSSDL MDKVNHLFNG  240
GDGDGDGDGV GEACSWGYNL NPDQGENDPA LWISEPIESG HVTPANHSNS NSNQISKLDK  300
NESSVENPRL QNPNFSTSGL NKDGNFRDGL MKSNETLSFM GEESNKRRSP VSKGSNNDEG  360
MLSFSTVVRS TAKSGDSDHS DLEASVVKEA IVVEPPEKKP RKRGRKPANG REEPLNHVEA  420
ERQRREKLNQ KFYSLRAVVP NVSKMDKASL LGDAISYINE LKTKLQQAEN DKEEIQKLLD  480
GMGKEGNGTR GRERKRGSNQ DSASSIEMEI DVKIIGWDVM IRVQCSKKNH PGARFMDALK  540
ELDLEVNHAS LSVVNELMIQ QATVKMGSQF FNHDQLKAAL MAKVG
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rru_A1e-116122348227Transcription factor MYC3
4ywc_A1e-116122348227Transcription factor MYC3
4ywc_B1e-116122348227Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1397405KKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. {ECO:0000269|PubMed:12136026, ECO:0000269|PubMed:21242320, ECO:0000269|PubMed:21321051, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:23943862}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00085PBMTransfer from AT5G46760Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK31432.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Barely up-regulated by jasmonic acid. {ECO:0000269|PubMed:21242320, ECO:0000269|PubMed:21335373}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK3527070.0AK352707.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-05-E20.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024010949.10.0transcription factor MYC3
SwissprotQ9FIP90.0MYC3_ARATH; Transcription factor MYC3
TrEMBLA0A087GNI00.0A0A087GNI0_ARAAL; Uncharacterized protein
STRINGA0A087GNI00.0(Arabis alpina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM12652896
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G46760.10.0bHLH family protein
Publications ? help Back to Top
  1. Chico JM, et al.
    Repression of Jasmonate-Dependent Defenses by Shade Involves Differential Regulation of Protein Stability of MYC Transcription Factors and Their JAZ Repressors in Arabidopsis.
    Plant Cell, 2014. 26(5): p. 1967-1980
    [PMID:24824488]
  2. Gasperini D, et al.
    Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth.
    PLoS Genet., 2015. 11(6): p. e1005300
    [PMID:26070206]
  3. Qi T, et al.
    Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis.
    Plant Cell, 2015. 27(6): p. 1634-49
    [PMID:26071420]
  4. de Torres Zabala M, et al.
    Novel JAZ co-operativity and unexpected JA dynamics underpin Arabidopsis defence responses to Pseudomonas syringae infection.
    New Phytol., 2016. 209(3): p. 1120-34
    [PMID:26428397]
  5. Yu J, et al.
    JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis.
    J. Exp. Bot., 2016. 67(3): p. 751-62
    [PMID:26547795]
  6. Chen X,Huang H,Qi T,Liu B,Song S
    New perspective of the bHLH-MYB complex in jasmonate-regulated plant fertility in arabidopsis.
    Plant Signal Behav, 2016. 11(2): p. e1135280
    [PMID:26829586]
  7. Schmiesing A,Emonet A,Gouhier-Darimont C,Reymond P
    Arabidopsis MYC Transcription Factors Are the Target of Hormonal Salicylic Acid/Jasmonic Acid Cross Talk in Response to Pieris brassicae Egg Extract.
    Plant Physiol., 2016. 170(4): p. 2432-43
    [PMID:26884488]
  8. Thatcher LF, et al.
    Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum.
    J. Exp. Bot., 2016. 67(8): p. 2367-86
    [PMID:26896849]
  9. Gao C, et al.
    MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis.
    Plant Physiol. Biochem., 2016. 108: p. 63-70
    [PMID:27415132]
  10. Gimenez-Ibanez S, et al.
    JAZ2 controls stomata dynamics during bacterial invasion.
    New Phytol., 2017. 213(3): p. 1378-1392
    [PMID:28005270]
  11. Zhang F, et al.
    Structural insights into alternative splicing-mediated desensitization of jasmonate signaling.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(7): p. 1720-1725
    [PMID:28137867]
  12. Lian TF,Xu YP,Li LF,Su XD
    Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA.
    Cell Rep, 2017. 19(7): p. 1334-1342
    [PMID:28514654]
  13. Wang H, et al.
    The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis.
    Mol Plant, 2017. 10(11): p. 1461-1464
    [PMID:28827172]
  14. Song S, et al.
    MYC5 is Involved in Jasmonate-Regulated Plant Growth, Leaf Senescence and Defense Responses.
    Plant Cell Physiol., 2017. 58(10): p. 1752-1763
    [PMID:29017003]
  15. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  16. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]