PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK29073.1
Organism
Arabis alpina
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family E2F/DP
Protein Properties Length: 382aa    MW: 42906.1 Da    PI: 5.2097
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK29073.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.71.8e-27139204171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                 r+++sL+llt+kf+kl++ +e+g+++ln++a+ L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  KFK29073.1 139 RYDSSLGLLTKKFVKLMQDAEDGTLDLNHCADVL---EV--QKRRIYDITNVLEGIGLIEKTTKNHIRWKG 204
                 6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.0E-29136206IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.2E-34139204IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467859.52E-18139202IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.4E-25141204IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146609.34E-42215322No hitNo description
SuperFamilySSF1440746.02E-29216321No hitNo description
PfamPF164215.2E-27220319IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 382 aa     Download sequence    Send to blast
MAATSNSGED PSLSYHHRSP FRFELLDSVP PDPLYSSTTT PSSTNRPFSV PNAQSAINPP  60
HWDDSYSLIT QKVQKSRKNH RIQLGSVAHM PGETIDIAKV IVKQESPQDV KRVGNKSKAG  120
LGKRMAEALS GVPNGGNCRY DSSLGLLTKK FVKLMQDAED GTLDLNHCAD VLEVQKRRIY  180
DITNVLEGIG LIEKTTKNHI RWKGADNLGQ KDLGDQIAKL KSEVECMQSE ESRLDDLIRE  240
RQEALRSLEE DENCRRYMFM TEEDITSLPC FQNQTLLAIK APTASYIEVP DPDEVMSFPQ  300
RQYRMVIRSR MGPIDVYLLS KYKGDSGETS DRPGHESDQN APSRVDTPSL KVVTSDTDLK  360
ADYWFESEAD VSLTDLWSNL SY
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-25133205174PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00190DAPTransfer from AT1G47870Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK29073.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF2425810.0AF242581.1 Arabidopsis thaliana E2F transcription factor-2 E2F2 mRNA, complete cds.
GenBankAJ4178340.0AJ417834.1 Arabidopsis thaliana mRNA for transcription factor E2Fc (e2Fc gene).
GenBankAY0456360.0AY045636.1 Arabidopsis thaliana At1g47870/T2E6_2 mRNA, complete cds.
GenBankAY0582310.0AY058231.1 Arabidopsis thaliana At1g47870/T2E6_2 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020870512.10.0transcription factor E2FC isoform X1
SwissprotQ9FV700.0E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A087GGS10.0A0A087GGS1_ARAAL; Uncharacterized protein
STRINGA0A087GGS10.0(Arabis alpina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.10.0E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]