PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK26334.1
Organism
Arabis alpina
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family E2F/DP
Protein Properties Length: 450aa    MW: 49542.8 Da    PI: 4.3809
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK26334.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.8e-27124189171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                 r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+i+wkg
  KFK26334.1 124 RYDSSLGLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIQWKG 189
                 6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.6E-29121191IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.9E-35124189IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.63E-17124187IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.5E-24126189IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.23E-45200306No hitNo description
SuperFamilySSF1440746.28E-32201306No hitNo description
PfamPF164214.5E-32205304IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 450 aa     Download sequence    Send to blast
MSESQKELPP PPPSSKRQHH LSMKPPLVAP GEYHRFDTAG GGDSDQVPDS IVIKSALKRK  60
TDFANQVAEP NELSTGVLQT PVSGKGGKAK KTPRSVKSNK SGTQATGSNA GSPGNNFAQA  120
GTCRYDSSLG LLTKKFINLI KQAEDGILDL NKAADTLEVQ KRRIYDITNV LEGIGLIEKT  180
LKNRIQWKGL DVSKPGETIE NIANLQDEIQ NLAAEEATLD DQIRESQERL TTLSEDENNK  240
RFLFVTEDDI KNLPCFQNKT LIAVKAPHGT TLEVPDPDEA GGYPQRRYRI ILRSTMGPID  300
VYLVSQFEER FEELPPTDEP SNIPSTSGPH ENQDVAMPME EDSTDKNTET QELDDTQKVY  360
SDIESQDFVD GIMKIVPPDL DMDVDYWLRS EVGEVSITDL WPNESGLDWN SMASFDQNHA  420
GPSNTTTLEQ PQTPSSPTPE DSTATKSTGS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A8e-25124190774PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK26334.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4000000.0AF400000.1 Thlaspi caerulescens E2F-related transcription factor 1 (E2F1) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006400728.20.0transcription factor E2FB isoform X1
SwissprotQ9FV710.0E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A087G8Y20.0A0A087G8Y2_ARAAL; Uncharacterized protein
STRINGA0A087G8Y20.0(Arabis alpina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.20.0E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]