PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; basal Magnoliophyta; Amborellales; Amborellaceae; Amborella

Family

E2F/DP

Protein Properties

Length: 430aa MW: 47917.7 Da PI: 5.0006

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
evm_27.model.AmTr_v1.0_scaffold00030.186	genome	TAGP	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.4	4.3e-27	138	203	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirw 69 r+++sL+llt+kf++l++++e+g+++ln++a+ L +v ++RRiYDi+NVLe+++liekk kn+irw evm_27.model.AmTr_v1.0_scaffold00030.186 138 RYDSSLGLLTKKFINLIKQAEDGVLDLNKAAEIL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRW 201 6899****************************...99..************************** PP E2F_TDP 70 kg 71 kg evm_27.model.AmTr_v1.0_scaffold00030.186 202 KG 203 98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.3E-29	136	205	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.0E-17	138	201	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.0E-34	138	203	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.9E-24	140	203	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	2.06E-50	214	320	No hit	No description
SuperFamily	SSF144074	2.88E-34	215	320	No hit	No description
Pfam	PF16421	5.2E-35	219	318	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 430 aa Download sequence Send to blast
MSGGRGLNRV HQPPGPVIHQ PLRRHLPFSS SKPSFANPGD YHQFSEAGKR EESDALVVTS 60 PLKRKYDTEE HEAESSDWAT SQGYAEVVNS PLHTPISIKG KGYSRGKASR YTKSGPPTPI 120 SNAGSPASNT LTPVGTCRYD SSLGLLTKKF INLIKQAEDG VLDLNKAAEI LEVQKRRIYD 180 ITNVLEGIGL IEKKLKNRIR WKGLDVSRPG EVDEDIAVLQ AEVQNLHLEE HRIDEQIREM 240 QKSLRDLSED ENNQKWLYVT EEDIKGLPCF QNETLIAIKA PHGTTLEVPD PDEAVEYPQR 300 RYQILLRSTM GPIDVYLVSQ FKKLEEVNSV ADSPLQPPQS TPDHVVTSSL PTTLETSRRV 360 EMEAEGQDGS QDFVGGFMKL VPSEIDTEAD YWLLSDPPGV SITEIWKADR ASAVHPDDGW 420 ERSTVLWYG*

Sequence ? help Back to Top

Protein Sequence Length: 430 aa Download sequence Send to blast

MSGGRGLNRV HQPPGPVIHQ PLRRHLPFSS SKPSFANPGD YHQFSEAGKR EESDALVVTS  60
PLKRKYDTEE HEAESSDWAT SQGYAEVVNS PLHTPISIKG KGYSRGKASR YTKSGPPTPI  120
SNAGSPASNT LTPVGTCRYD SSLGLLTKKF INLIKQAEDG VLDLNKAAEI LEVQKRRIYD  180
ITNVLEGIGL IEKKLKNRIR WKGLDVSRPG EVDEDIAVLQ AEVQNLHLEE HRIDEQIREM  240
QKSLRDLSED ENNQKWLYVT EEDIKGLPCF QNETLIAIKA PHGTTLEVPD PDEAVEYPQR  300
RYQILLRSTM GPIDVYLVSQ FKKLEEVNSV ADSPLQPPQS TPDHVVTSSL PTTLETSRRV  360
EMEAEGQDGS QDFVGGFMKL VPSEIDTEAD YWLLSDPPGV SITEIWKADR ASAVHPDDGW  420
ERSTVLWYG*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-23	133	204	1	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00661	PBM	Transfer from Pp3c1_6880	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011627152.1	0.0	transcription factor E2FA
Refseq	XP_020529414.1	0.0	transcription factor E2FA
Swissprot	Q9FV71	1e-133	E2FB_ARATH; Transcription factor E2FB
TrEMBL	U5D432	0.0	U5D432_AMBTC; Uncharacterized protein
STRING	ERN16172	0.0	(Amborella trichopoda)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Representative plant	OGRP1225	17	49

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-136	E2F transcription factor 1

Link Out ? help Back to Top
Phytozome	evm_27.model.AmTr_v1.0_scaffold00030.186

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Amborella Genome Project The Amborella genome and the evolution of flowering plants. Science, 2013. 342(6165): p. 1241089 [PMID:24357323] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]