PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Zoysieae; Zoysiinae; Zoysia

Family

MYB

Protein Properties

Length: 272aa MW: 30658.8 Da PI: 10.0868

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Zpz_sc00649.1.g00170.1.am.mkhc	genome	ZGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	48.9	1.5e-15	14	54	7	48
HHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 7 eEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +Ede++++ v++lG++ W+tIa+ ++ gR +kqc++rw+++l Zpz_sc00649.1.g00170.1.am.mkhc 14 QEDEIIIQMVNKLGPKKWSTIAQALP-GRIGKQCRERWHNHL 54 6***********************.***********97 PP
2	Myb_DNA-binding	30.8	6.8e-10	60	91	1	34
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkg 34 + +WT+eE+ +l++a++ +G++ W+ ++ ++ g Zpz_sc00649.1.g00170.1.am.mkhc 60 KEAWTQEEEIRLIHAHQTYGNK-WAELSKFLP-G 91 579*****************.*****99.3 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	23.089	1	58	IPR017930	Myb domain
SMART	SM00717	7.4E-9	13	56	IPR001005	SANT/Myb domain
CDD	cd00167	2.75E-12	14	54	No hit	No description
SuperFamily	SSF46689	1.15E-21	14	91	IPR009057	Homeodomain-like
Pfam	PF13921	1.2E-15	14	71	No hit	No description
Gene3D	G3DSA:1.10.10.60	2.2E-23	14	61	IPR009057	Homeodomain-like
SMART	SM00717	3.4E-7	59	128	IPR001005	SANT/Myb domain
PROSITE profile	PS51294	8.128	59	105	IPR017930	Myb domain
Gene3D	G3DSA:1.10.10.60	1.4E-13	62	104	IPR009057	Homeodomain-like
CDD	cd00167	2.11E-5	62	91	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 272 aa Download sequence Send to blast
MFHVGCSFII SYFQEDEIII QMVNKLGPKK WSTIAQALPG RIGKQCRERW HNHLNPGINK 60 EAWTQEEEIR LIHAHQTYGN KWAELSKFLP GSGISLGRRQ VGPRAQPRLR ATRLEQQLLQ 120 QYEYMNIMAD TPSVKRGLES PSAWKSPLFT AFQGAYFMSP AARAFDALGL VKQINDQRAD 180 ALEEAHEVLA SGSTKNRHSK GKWDKENTKS SLWNNGLIIS KLSSEVMAEA RVLDFNDCST 240 PARKKDDRNV DSKLGGSASS PVASSYIRMN VR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1gv2_A	2e-29	14	91	10	87	MYB PROTO-ONCOGENE PROTEIN
1mse_C	1e-29	14	91	10	87	C-Myb DNA-Binding Domain
1msf_C	1e-29	14	91	10	87	C-Myb DNA-Binding Domain
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (PubMed:21862669). Involved in the regulation of cytokinesis, probably via the activation of several G2/M phase-specific genes transcription (e.g. KNOLLE) (PubMed:17287251, PubMed:21862669, PubMed:25806785). Required for the maintenance of diploidy (PubMed:21862669). {ECO:0000269\|PubMed:17287251, ECO:0000269\|PubMed:21862669, ECO:0000269\|PubMed:25806785}.; FUNCTION: Involved in transcription regulation during induced endoreduplication at the powdery mildew (e.g. G.orontii) infection site, thus promoting G.orontii growth and reproduction. {ECO:0000269\|PubMed:20018666}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Zpz_sc00649.1.g00170.1.am.mkhc

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Slightly induced by salicylic acid (SA) (PubMed:16463103). Expressed in a cell cycle-dependent manner, with highest levels 2 hours before the peak of mitotic index in cells synchronized by aphidicolin. Activated by CYCB1 (PubMed:17287251). Accumulates at powdery mildew (e.g. G.orontii) infected cells. {ECO:0000269\|PubMed:16463103, ECO:0000269\|PubMed:17287251}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	BT017128	8e-59	BT017128.1 Zea mays clone EL01N0365C01.c mRNA sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_025808581.1	9e-64	transcription factor MYB3R-1-like
Refseq	XP_025808582.1	9e-64	transcription factor MYB3R-1-like
Swissprot	Q94FL9	5e-39	MB3R4_ARATH; Transcription factor MYB3R-4
TrEMBL	A0A0A9D3C2	2e-72	A0A0A9D3C2_ARUDO; Uncharacterized protein
STRING	Si021218m	3e-63	(Setaria italica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP2495	38	79

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G11510.1	2e-41	myb domain protein 3r-4

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Saito T, et al. Genetic interaction between G2/M phase-specific transcription factor MYB3R4 and MAPKKK ANP3 for execution of cytokinesis in Arabidopsis thaliana. Plant Signal Behav, 2015. 10(3): p. e990817 [PMID:25806785] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Chen P, et al. Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nat Commun, 2017. 8(1): p. 635 [PMID:28935922]