PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010532793.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya
Family bHLH
Protein Properties Length: 352aa    MW: 40027 Da    PI: 5.8389
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010532793.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.42.3e-12168219155
                     CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                     +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  XP_010532793.1 168 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 219
                     79****************************...9*****************9995 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.1E-13166222IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.43E-12166223No hitNo description
PROSITE profilePS5088815.428167218IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474599.29E-17167236IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.0E-9168219IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9173224IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048730.00243278342No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 352 aa     Download sequence    Send to blast
MLSYLKPDFF QALNHLGESS DGGHDDDNVG MIDYMLSNSL QQQPEHEMSP GFDEASPSFD  60
KLSFPDAVMQ FSDFGPKPTL NHTKIRDQDQ ETGIDPVYFL KFPVLNDNIQ DHHQIQPPMV  120
FREGKEGQEA RVLDRNNNSE NKNMSENEAK GKRKRRRTIK TSEEVESQRM THIAVERNRR  180
KQMNEHLRVL RSLMPGSYVQ RGDQASIIGG AIEFVRELEQ LLQCLESQKR RRLSETASSS  240
SPSPSPLNFP ANESEEETAE KKSCFADVEV KILGFDAMIK ILSRSRPGQL VKTISALEDL  300
RLCVLHANIT TIEQTVLYSF SVKMTSEKRF TAEDIANSIQ QIFSFIHANT AM
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1151156KRKRRR
2152156RKRRR
3152157RKRRRT
4168179RMTHIAVERNRR
5228232KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010532793.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010532793.10.0PREDICTED: transcription factor FAMA
SwissprotQ56YJ81e-146FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A398A5T51e-155A0A398A5T5_BRACM; Uncharacterized protein
STRINGXP_010532793.10.0(Tarenaya hassleriana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM55482649
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-121bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]