PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Sopen05g032160.1

Organism

Solanum pennellii

Taxonomic ID

28526

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon

Family

bHLH

Protein Properties

Length: 382aa MW: 43271.6 Da PI: 4.9963

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Sopen05g032160.1	genome	spenn	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	38.2	2.6e-12	165	216	1	55
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h ++Er+RR+++N+ + Lr+l+P + + ++ + a+i A+e++++L+ Sopen05g032160.1 165 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 216 79**************************...9***************9995 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd00083	1.61E-12	163	220	No hit	No description
Gene3D	G3DSA:4.10.280.10	1.3E-13	163	219	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	15.428	164	215	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	1.44E-16	164	230	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	1.2E-9	165	216	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.4E-9	170	221	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd04873	0.00301	304	368	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010377	Biological Process	guard cell fate commitment
GO:0045597	Biological Process	positive regulation of cell differentiation
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051782	Biological Process	negative regulation of cell division
GO:0005634	Cellular Component	nucleus
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 382 aa Download sequence Send to blast
MEKEENCQAN TLPTSFQMAI IGESSSNNTN NQMVDYMVNS QSIQQQQHNQ SSLGFLPSNP 60 SLDKLSFADV MQFADFGPKL ALNQTKVLEQ DVGIDDPVYF LKFPVLNEKK NDNDNDDDHE 120 EGLMISGGKE KGENNNNIVE KNQEGKSNNK RKRPRIKTSE EVESQRMTHI AVERNRRKQM 180 NEHLRVLRSL MPGSYVQRGD QASIIGGAIE FVRELEQLLQ CLESQKRRRI YGDTPTRPLG 240 DSSTPPSMPM NQNPNAINPH HHQSPILFPL PNEYNIEDEI QEEVAESKSC LADVEVKLLG 300 FDAMIKILSR RRPGQLIKAI AALEDMQLSI LHTNITTIEQ TVLYSFNVKI SGETRYTADD 360 IANSIQQIFS FIHAEIAPYD IN

Sequence ? help Back to Top

Protein Sequence Length: 382 aa Download sequence Send to blast

MEKEENCQAN TLPTSFQMAI IGESSSNNTN NQMVDYMVNS QSIQQQQHNQ SSLGFLPSNP  60
SLDKLSFADV MQFADFGPKL ALNQTKVLEQ DVGIDDPVYF LKFPVLNEKK NDNDNDDDHE  120
EGLMISGGKE KGENNNNIVE KNQEGKSNNK RKRPRIKTSE EVESQRMTHI AVERNRRKQM  180
NEHLRVLRSL MPGSYVQRGD QASIIGGAIE FVRELEQLLQ CLESQKRRRI YGDTPTRPLG  240
DSSTPPSMPM NQNPNAINPH HHQSPILFPL PNEYNIEDEI QEEVAESKSC LADVEVKLLG  300
FDAMIKILSR RRPGQLIKAI AALEDMQLSI LHTNITTIEQ TVLYSFNVKI SGETRYTADD  360
IANSIQQIFS FIHAEIAPYD IN

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	165	176	RMTHIAVERNRR
2	225	229	KRRRI

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	HG975444	0.0	HG975444.1 Solanum pennellii chromosome ch05, complete genome.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015074929.1	0.0	transcription factor FAMA-like
Refseq	XP_015074930.1	0.0	transcription factor FAMA-like
Swissprot	Q56YJ8	1e-131	FAMA_ARATH; Transcription factor FAMA
TrEMBL	M1BAD1	0.0	M1BAD1_SOLTU; Uncharacterized protein
STRING	PGSC0003DMT400040761	0.0	(Solanum tuberosum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA4657	23	41

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	1e-107	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]