PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Sobic.004G168300.1.p
Organism
Sorghum bicolor
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum
Family E2F/DP
Protein Properties Length: 472aa    MW: 52038.7 Da    PI: 5.0322
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Sobic.004G168300.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.32e-26145209170
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 
                           r+++sL+llt+kf++ll+++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+irwk
  Sobic.004G168300.1.p 145 RYDSSLGLLTKKFINLLKQAPDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWK 209
                           6899******************************...99..****************************8 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-27143211IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.25E-18145208IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.3E-34145210IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.6E-24147209IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440747.59E-25241324No hitNo description
CDDcd146605.34E-38243324No hitNo description
PfamPF164214.5E-25243322IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 472 aa     Download sequence    Send to blast
MSGLGSGRPQ AAQKILQSLR PPLSFASPSR PPFAAPDEYH RFPTPAAATG PGATSGGVGV  60
GGDPPDTIEE GLVLRTPLKR KARSVENDTA ESSDCIITSP MLTPVSGKTV KASKAKAKNS  120
KAGPQTPTSN VGSPLNPPTP VGTCRYDSSL GLLTKKFINL LKQAPDGILD LNNAAETLEV  180
QKRRIYDITN VLEGIGLIEK TLKNRIRWKA LDDSSVHLDN GISALQFLTK ALCNQVLCFP  240
FSDMREKLRE LTEDENNKRW IYVTEDDIKG LPSFQNYTLI AIKAPHGTTL EVPDPDEAGD  300
YLQRRYRIVL RSTMGPIDVY LVSQFDENIE ELGDVMPRHQ PTEDFNTTYA AQSSTPIDVA  360
HDVQQSQKIP QDPSTLHDFG GMTRLTASDV QTSDYWLLTE GDVSMTDIWR TERILDNHSL  420
SYLKFLAWKI EEVQWDQMDF LSEDVVTPRA HNQQPVTADG PHMEVPSMDK P*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-23137211274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
17783LKRKARS
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapSobic.004G168300.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJX4699630.0JX469963.1 Zea mays subsp. mays clone UT3225 E2F-DP-type transcription factor mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002453944.20.0transcription factor E2FA
SwissprotQ9FNY01e-114E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1Z5RMW70.0A0A1Z5RMW7_SORBI; Uncharacterized protein
STRINGAC233850.1_FGP0050.0(Zea mays)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.31e-104E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]