PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Potri.012G075300.1
Common NamePOPTR_0012s07700g
Organism
Populus trichocarpa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus
Family E2F/DP
Protein Properties Length: 386aa    MW: 43366.6 Da    PI: 8.949
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Potri.012G075300.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.22.9e-232085171
             E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                        rk+ksL+ll+++fl+l+ + + +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn++ wkg
  Potri.012G075300.1 20 RKQKSLGLLCTNFLTLYDRDDIDVIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLARKAKNKYLWKG 85
                        79****************9999************...**..****************************98 PP
2E2F_TDP71.87.8e-23156236171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                         r+eksL+lltq+f+kl+ + +++ ++l+e ak L+ +      +++k+RR+YDi+NVL++l+liek     ++k+++rw g
  Potri.012G075300.1 156 RREKSLGLLTQNFVKLFVCFNANLISLDESAKLLLGDghkssIMRTKVRRLYDIANVLSSLKLIEKthtadTRKPAFRWLG 236
                         689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.6E-251686IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.41E-151983IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.4E-282085IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-192185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.7E-21154237IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.1E-27156236IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467857.62E-12158237IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023198.4E-18158236IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MALSYSDIID PSSRHHTYSR KQKSLGLLCT NFLTLYDRDD IDVIGLDDAA SKLGVERRRI  60
YDIVNVLESV GVLARKAKNK YLWKGFAAVP KALQELKEEG LRDNVNTIDK QSNNSVKVAD  120
DDEDEDDDSD SNPNTGSQNE NSGIIKSTAA SRFDHRREKS LGLLTQNFVK LFVCFNANLI  180
SLDESAKLLL GDGHKSSIMR TKVRRLYDIA NVLSSLKLIE KTHTADTRKP AFRWLGLRGK  240
SENGSGDPLA PFESRKRTFG ADVTNICSKR NKTDSSVDGD KSKNLKMQKQ IKDENIVTVV  300
QRGNFDQDSQ QNSGSFQFGP FAPVSIARVG NSEEKVTQIY DWEGLSSTFR PQYHNQALRD  360
LFFHYTEAWK SWYTEVAGKK PLHIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-37192283228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapPotri.012G075300.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002318015.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-127E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLB9I3490.0B9I349_POPTR; Uncharacterized protein
STRINGPOPTR_0012s07700.10.0(Populus trichocarpa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Representative plantOGRP24741634
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-122DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]