PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Pbr015398.1

Organism

Pyrus bretschneideri

Taxonomic ID

225117

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Pyrus

Family

E2F/DP

Protein Properties

Length: 481aa MW: 53158.6 Da PI: 5.3827

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Pbr015398.1	genome	CPETR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.9	3.1e-27	155	220	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg Pbr015398.1 155 RYDSSLGLLTKKFINLIKRAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 220 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	5.2E-29	152	222	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.05E-16	155	218	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	4.5E-34	155	220	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.5E-24	157	220	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	4.97E-34	233	337	No hit	No description
CDD	cd14660	1.17E-48	233	337	No hit	No description
Pfam	PF16421	6.7E-33	236	335	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 481 aa Download sequence Send to blast
MSGCARAPNR QPAPATAGTG GGGPILPPLR RHXXXXLPPL RRHLAFESTK PQPFPPDNYH 60 RFAGGARRAG DQEPEDIYVR SPQLTRKDNN EVEYSDWTCS PGNTNIIQSP LLTPPMSAKG 120 GRVNNRSKAS KGGRSGPQTP VSNVGSPSTP AGSCRYDSSL GLLTKKFINL IKRAEDGILD 180 LNKAAETLEV QKRRIYDITN VLEGIGLIEK KLKNRIRWKG FDASMPGELD GDLSILQAEV 240 ENLSLQERRL DDRIREMQEK LRDLSEDENN QKWLFVTEDD IKGLPCFHNE TLIAIKAPHG 300 TTLEVPDPDE AVDYPRRRYR IILRSTMGPI DVYLVSQFEE KFEDVHGAEP PVSFPMASVS 360 GSSEHPITEV VTVESSGKEI EPWPQQAHHL CSDLNASQEF AGGMMKIVPS DVDNDADYWL 420 LSDAEVSITD MWRTDSGVGW NGTDILHADF GVTDVSTPRP QTPPSRVVEV PSHAVNFAQR 480 *

Sequence ? help Back to Top

Protein Sequence Length: 481 aa Download sequence Send to blast

MSGCARAPNR QPAPATAGTG GGGPILPPLR RHXXXXLPPL RRHLAFESTK PQPFPPDNYH  60
RFAGGARRAG DQEPEDIYVR SPQLTRKDNN EVEYSDWTCS PGNTNIIQSP LLTPPMSAKG  120
GRVNNRSKAS KGGRSGPQTP VSNVGSPSTP AGSCRYDSSL GLLTKKFINL IKRAEDGILD  180
LNKAAETLEV QKRRIYDITN VLEGIGLIEK KLKNRIRWKG FDASMPGELD GDLSILQAEV  240
ENLSLQERRL DDRIREMQEK LRDLSEDENN QKWLFVTEDD IKGLPCFHNE TLIAIKAPHG  300
TTLEVPDPDE AVDYPRRRYR IILRSTMGPI DVYLVSQFEE KFEDVHGAEP PVSFPMASVS  360
GSSEHPITEV VTVESSGKEI EPWPQQAHHL CSDLNASQEF AGGMMKIVPS DVDNDADYWL  420
LSDAEVSITD MWRTDSGVGW NGTDILHADF GVTDVSTPRP QTPPSRVVEV PSHAVNFAQR  480
*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-24	147	221	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Pbr015398.1

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009372588.2	0.0	PREDICTED: transcription factor E2FA-like
Swissprot	Q9FNY0	1e-169	E2FA_ARATH; Transcription factor E2FA
TrEMBL	M5W8E6	0.0	M5W8E6_PRUPE; Uncharacterized protein
STRING	XP_009372588.1	0.0	(Pyrus x bretschneideri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-173	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]