PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PK11630.1
Organism
Cannabis sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis
Family E2F/DP
Protein Properties Length: 462aa    MW: 51355.4 Da    PI: 4.5754
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PK11630.1genomeCCBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.9e-27140205171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  PK11630.1 140 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 205
                6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.4E-29138206IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.2E-35140205IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.24E-17140203IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.6E-24142205IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.22E-46216322No hitNo description
SuperFamilySSF1440741.28E-32217322No hitNo description
PfamPF164211.4E-32221320IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 462 aa     Download sequence    Send to blast
MSGAQASNPS AQPSEQIRQP LKPHQLPFSS MKPPFSVPAD YHRFGPETHR LTDHEAEGIV  60
VKPLLKRKVD IVDYEVESSD RAGPRFEVVN SSLQTPVSVK AGKATKTSRL TKCSKARPQT  120
PISNVGSPSG PNLTPAGPCR YDSSLGLLTK KFINLIKHAE DGILDLNKAA DTLEVQKRRI  180
YDITNVLEGI GLIEKKLKNR IQWKGLDISR PGDADDNYAS LQAEVEKLSV EERTVDEQIR  240
EMEERLRDLS EDENNQKWLF VTEDDIKGLP CFQNETLIAI KAPHGTTLEV PDPDEDVDYR  300
QRRYRVVLRS TMGPIDVYLV SQFEEKFEEI DGVQVPANIP SCSGVNENPA TMDMADGGKD  360
DSTKLQRQHD HETCVDPNAP QDSVSGIMKI VPSDVDSEAD YWLLTDAADV SITDMWNTEP  420
SVEWNDFVLP EDYPAVTVGT PKPQTLPSNP TEVPSTVNNT GR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-27135206274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015868390.10.0transcription factor E2FB-like isoform X2
RefseqXP_024025053.10.0transcription factor E2FB isoform X2
SwissprotQ9FV711e-152E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A2P5CPL00.0A0A2P5CPL0_TREOI; E2F Family
STRINGXP_010102033.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-143E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]