PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf04654g04001.1
Organism
Nicotiana benthamiana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 420aa    MW: 47538.9 Da    PI: 9.066
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf04654g04001.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.21.4e-2373138171
                   E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                               rk+ksL+ll+++fl+l++++  +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Niben101Scf04654g04001.1  73 RKQKSLGLLCSNFLSLYNREGIETIGLDDAARRL---GV--ERRRIYDIVNVLESIGVLARKAKNRYSWKG 138
                               79*****************999************...**..****************************98 PP
2E2F_TDP74.61e-23187267171
                   E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                               r+eksL+lltq+f+kl+ +++ ++++l+e+ak L+ +      +++k+RR+YDi+NVL++++ iek     ++k+++rw g
  Niben101Scf04654g04001.1 187 RREKSLGLLTQNFVKLFLCTDVDMICLDEAAKILLGDgrppaMTRTKVRRLYDIANVLSSMKFIEKthhpeTRKPAFRWLG 267
                               689**************************************99999*********************99999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.6E-2669139IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.8E-2873138IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.72E-1573136IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.8E-2074138IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.8E-23182268IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.0E-31187267IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.2E-18189267IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.72E-11189268IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 420 aa     Download sequence    Send to blast
MAHFHPANVN KPFLNGSFFL KHEFSLFYID PISESLTKFG HTRTHTVDLI SSKKNIMSLA  60
SDPSKDSRST YCRKQKSLGL LCSNFLSLYN REGIETIGLD DAARRLGVER RRIYDIVNVL  120
ESIGVLARKA KNRYSWKGFG AIPWTLQQLK GSDEDDDDSD SKPIASSHTE TLNPNSNSAA  180
ASKSDNRREK SLGLLTQNFV KLFLCTDVDM ICLDEAAKIL LGDGRPPAMT RTKVRRLYDI  240
ANVLSSMKFI EKTHHPETRK PAFRWLGMRE RSDDKAVDTL DATESKKRVF GTELTNTTIK  300
KNRVALPTDG ISDEVTRKHL LTEVKCENLE NDLHCPKQEP GLTSSKKSYH FGPFAPPSLA  360
QAEASEADRM KQVHDWESLA STYRPQYHNQ ALKDLFAHYV EAWKSWYLEV AGKNPIQLIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-34732594228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019233450.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-114E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1J6KF880.0A0A1J6KF88_NICAT; E2f transcription factor-like e2fe
STRINGXP_009607525.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-112DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]