PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_11737_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family C2H2
Protein Properties Length: 279aa    MW: 31434.8 Da    PI: 8.5505
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_11737_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H222.72.6e-07134155223
                     EETTTTEEESSHHHHHHHHHHT CS
         zf-C2H2   2 kCpdCgksFsrksnLkrHirtH 23 
                      C +Cgk F+r  nL+ H+r H
  Neem_11737_f_1 134 FCDICGKGFKRDANLRMHMRAH 155
                     6*******************99 PP
2zf-C2H212.70.00039218241123
                     EEETTTT.EEESSHHHHHHHHHHT CS
         zf-C2H2   1 ykCpdCg.ksFsrksnLkrHirtH 23 
                     ++C +C+ k+F   s+Lk+H +++
  Neem_11737_f_1 218 FSCDKCNkKRFAVLSDLKSHHKNC 241
                     89*******************997 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576671.06E-6129158No hitNo description
SMARTSM003550.0017133155IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.632133160IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.601.4E-6135160IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS000280135155IPR007087Zinc finger, C2H2
SMARTSM0035553180213IPR015880Zinc finger, C2H2-like
SMARTSM00355130218239IPR015880Zinc finger, C2H2-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 279 aa     Download sequence    Send to blast
MSNPHESRSV RREYPLENSD PGTPLTNLSA VRTRMDSLQQ FLSQSVNSNT LISQHQMNMV  60
SSEIASAIHQ IIVNGAALLA CSQQPIPPST DPQNPDVASV SEKTEQVSEK TECELDCDIM  120
EIDAVELLAE HIHFCDICGK GFKRDANLRM HMRAHGNEYK TPEALAKPDK GNEPGRKTRF  180
SCPYEGCNRN KKHKKFRPLK SVVCVKNHFK RSHCPKMFSC DKCNKKRFAV LSDLKSHHKN  240
CGESRWKCSC GTSFSRKDKL FGHVALFEGH MPEAVYGNM
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor. Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269|PubMed:17535918, ECO:0000269|PubMed:18826429, ECO:0000269|PubMed:19321711, ECO:0000269|PubMed:23935008}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By shock H(+) and Al(3+) treatments. {ECO:0000269|PubMed:17535918}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006428216.11e-156zinc finger protein STOP1 homolog
RefseqXP_006464195.11e-156zinc finger protein STOP1 homolog
SwissprotQ9C8N53e-77STOP1_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
TrEMBLV4SW991e-155V4SW99_9ROSI; Uncharacterized protein
STRINGXP_006464195.11e-155(Citrus sinensis)
STRINGXP_006428216.11e-155(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM57522547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G34370.21e-79C2H2 family protein
Publications ? help Back to Top
  1. Kobayashi Y, et al.
    Molecular and physiological analysis of Al³⁺ and H⁺ rhizotoxicities at moderately acidic conditions.
    Plant Physiol., 2013. 163(1): p. 180-92
    [PMID:23839867]
  2. Yokosho K,Yamaji N,Ma JF
    Global transcriptome analysis of Al-induced genes in an Al-accumulating species, common buckwheat (Fagopyrum esculentum Moench).
    Plant Cell Physiol., 2014. 55(12): p. 2077-91
    [PMID:25273892]
  3. Geng X, et al.
    LEUNIG_HOMOLOG transcriptional co-repressor mediates aluminium sensitivity through PECTIN METHYLESTERASE46-modulated root cell wall pectin methylesterification in Arabidopsis.
    Plant J., 2017. 90(3): p. 491-504
    [PMID:28181322]
  4. Balzergue C, et al.
    Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation.
    Nat Commun, 2017. 8: p. 15300
    [PMID:28504266]
  5. Pelagio-Flores R,Esparza-Reynoso S,Garnica-Vergara A,López-Bucio J,Herrera-Estrella A
    Trichoderma-Induced Acidification Is an Early Trigger for Changes in Arabidopsis Root Growth and Determines Fungal Phytostimulation.
    Front Plant Sci, 2017. 8: p. 822
    [PMID:28567051]
  6. Jiang F, et al.
    Identification and characterization of suppressor mutants of stop1.
    BMC Plant Biol., 2017. 17(1): p. 128
    [PMID:28738784]
  7. Daspute AA, et al.
    Transcriptional Regulation of Aluminum-Tolerance Genes in Higher Plants: Clarifying the Underlying Molecular Mechanisms.
    Front Plant Sci, 2017. 8: p. 1358
    [PMID:28848571]
  8. Sharma A,Wai CM,Ming R,Yu Q
    Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis.
    Genome Biol Evol, 2017. 9(9): p. 2170-2190
    [PMID:28922793]
  9. Zhang Y, et al.
    The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis.
    Front Plant Sci, 2018. 9: p. 118
    [PMID:29491872]