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Plant Transcription
Factor Database
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Transcription Factor Information
Basic
Information? help
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TF ID |
Medtr0194s0050.1 |
Common Name | MTR_0194s0050 |
Organism |
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Taxonomic ID |
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Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
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Family |
bHLH |
Protein Properties |
Length: 388aa MW: 43989.3 Da PI: 5.1138 |
Description |
bHLH family protein |
Gene Model |
Gene Model ID |
Type |
Source |
Coding Sequence |
Medtr0194s0050.1 | genome | Mt | View CDS |
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Signature Domain? help Back to Top |
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No. |
Domain |
Score |
E-value |
Start |
End |
HMM Start |
HMM End |
1 | HLH | 38.2 | 2.6e-12 | 182 | 233 | 1 | 55 |
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
+r++h ++Er+RR+++N+ + Lr+l+P + + ++ + a+i A+e++++L+
Medtr0194s0050.1 182 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 233
79****************************...9*****************9995 PP
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Gene Ontology ? help Back to Top |
GO Term |
GO Category |
GO Description |
GO:0010377 | Biological Process | guard cell fate commitment |
GO:0045597 | Biological Process | positive regulation of cell differentiation |
GO:0045893 | Biological Process | positive regulation of transcription, DNA-templated |
GO:0051782 | Biological Process | negative regulation of cell division |
GO:0005634 | Cellular Component | nucleus |
GO:0046983 | Molecular Function | protein dimerization activity |
Sequence ? help Back to Top |
Protein Sequence Length: 388 aa
Download sequence Send
to blast |
MPSSFNTLDY SLDHHHHQQQ QQYEQLLKYR VGETSGENNN GMVDNYMPQT QTSGGFYGAN 60 SFDKMSFADV MQFADFGPKL ALNREESGIE DPVYFLKFPV LNNKIEDQNL MLSGDDGLGE 120 NDERFKLTSV EDKSRDQQDH EEARVSDENN SVQEKNCAVV QENNKKRKRP RTVKTSEEVE 180 SQRMTHIAVE RNRRKQMNEH LRVLRSLMPG SYVQRGDQAS IIGGAIEFVR ELEQLLQCLE 240 SQKRRRLLGE AQSKQVGDSS LASTQQQPPF FPATLPNDQM KLVEMETGLQ EETAESKSCL 300 ADVEVKLLGF DAMIKILSRR RPGQLIKTIA ALEDMQLIIL HTNITTIEQT VLYSFNVKVA 360 SDTRFTAEDI ASSVQQILSF IHANTSM*
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Nucleic Localization
Signal ? help
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No. |
Start |
End |
Sequence |
1 | 182 | 193 | RMTHIAVERNRR |
2 | 242 | 246 | KRRRL |
Expression --
Description ? help
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Source |
Description |
Uniprot | DEVELOPMENTAL STAGE: Not expressed in meristemoids, but strongly expressed in guard mother cells (GMCs) and in young guard cells (at protein level) (PubMed:17088607). Expressed at the transition to terminal stomatal differentiation, just before and after the symmetric division of stomatal differentiation, being confined to late-stage GMC and to young, still differentiating guard cells (PubMed:24571519). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:24571519}. |
Uniprot | TISSUE SPECIFICITY: Resctricted to stomatal cell lineages (at protein level). Expressed in roots, leaves, stems, and flowers. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:17088607}. |
Functional Description ? help
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Source |
Description |
UniProt | Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}. |
Regulation -- Description ? help
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Source |
Description |
UniProt | INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}. |
Publications
? help Back to Top |
- Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] - Young ND, et al.
The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature, 2011. 480(7378): p. 520-4 [PMID:22089132] - Matos JL, et al.
Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] - Chen L, et al.
NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] - Lee JH,Jung JH,Park CM
Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] - Han X, et al.
Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] - Li X,Yang R,Chen H
The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]
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