PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Lus10004217

Organism

Linum usitatissimum

Taxonomic ID

4006

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Linaceae; Linum

Family

E2F/DP

Protein Properties

Length: 451aa MW: 49935.1 Da PI: 5.0044

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Lus10004217	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	84.1	1.1e-26	118	183	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++ +e+gi++ln++a++L +v ++RRiYDi+NVLe+ +liek+ kn+irwkg Lus10004217 118 RYDSSLGLLTKKFVNLIKVAEDGIIDLNKAAETL---EV--QKRRIYDITNVLEGTGLIEKTLKNRIRWKG 183 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	9.8E-28	115	184	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	7.07E-17	118	181	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.0E-33	118	183	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	3.9E-23	120	183	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.53E-50	194	300	No hit	No description
SuperFamily	SSF144074	3.4E-33	197	300	No hit	No description
Pfam	PF16421	1.1E-34	199	298	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 451 aa Download sequence Send to blast
MRRHLAFVSM MPPFVAPDDY HRFSTPPASS KVADRDAEAI VVRSPAFKRK LKLDDTGIDS 60 TKWTTNAGHT DPSSSPFQTP TKGGRTYKPK STKANKALPQ TPVSNPGSPS TLTPSGTRYD 120 SSLGLLTKKF VNLIKVAEDG IIDLNKAAET LEVQKRRIYD ITNVLEGTGL IEKTLKNRIR 180 WKGVGGSDSG NVDNNASLLQ AEIERLSLEE QNLDNQIREM SERLRNLSED ENNQKWLFLT 240 EDDIKNLPCF QNQTLIAIKA PHGTTLEVPD PDEAVDYAQR RYRIILRSTM GPIDVYLVSQ 300 FEENFEEAID TGPSTSVDHA SSSSSSVNPH MVSTQGTQKA VEPQPQPSPQ PPVQDDHHMF 360 SDFNSSQELV GGMMKIVPSD ADNETDYWLL SDAADISITD MWKADGMLAD FYPSPSTPPR 420 PVSPTQLTQF SISTFRCIVF SLMLQLMLTV *

Sequence ? help Back to Top

Protein Sequence Length: 451 aa Download sequence Send to blast

MRRHLAFVSM MPPFVAPDDY HRFSTPPASS KVADRDAEAI VVRSPAFKRK LKLDDTGIDS  60
TKWTTNAGHT DPSSSPFQTP TKGGRTYKPK STKANKALPQ TPVSNPGSPS TLTPSGTRYD  120
SSLGLLTKKF VNLIKVAEDG IIDLNKAAET LEVQKRRIYD ITNVLEGTGL IEKTLKNRIR  180
WKGVGGSDSG NVDNNASLLQ AEIERLSLEE QNLDNQIREM SERLRNLSED ENNQKWLFLT  240
EDDIKNLPCF QNQTLIAIKA PHGTTLEVPD PDEAVDYAQR RYRIILRSTM GPIDVYLVSQ  300
FEENFEEAID TGPSTSVDHA SSSSSSVNPH MVSTQGTQKA VEPQPQPSPQ PPVQDDHHMF  360
SDFNSSQELV GGMMKIVPSD ADNETDYWLL SDAADISITD MWKADGMLAD FYPSPSTPPR  420
PVSPTQLTQF SISTFRCIVF SLMLQLMLTV *

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-24	106	185	2	75	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Lus10004217

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	HQ886518	4e-40	HQ886518.1 Linum usitatissimum clone GMU2AYZ01AXZVR microsatellite sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015898822.1	0.0	transcription factor E2FA isoform X2
Swissprot	Q9FNY0	1e-155	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2P5Y1W5	0.0	A0A2P5Y1W5_GOSBA; Uncharacterized protein
STRING	Lus10004217	0.0	(Linum usitatissimum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-153	E2F transcription factor 3

Link Out ? help Back to Top
Phytozome	Lus10004217

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]