PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KZV34856.1
Organism
Dorcoceras hygrometricum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Gesneriaceae; Didymocarpoideae; Trichosporeae; Loxocarpinae; Dorcoceras
Family bHLH
Protein Properties Length: 381aa    MW: 42573.2 Da    PI: 5.7233
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KZV34856.1genomeCNUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.35.7e-13174225155
                 CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
         HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                 +r++h ++Er+RR+++N+ +  Lr+l+P++   + ++ + a+i   A+e++++L+
  KZV34856.1 174 QRMTHIAVERNRRKQMNEHLRVLRSLMPSS---YVQRGDQASIIGGAIEFVRELE 225
                 79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.106.3E-14172228IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000836.29E-13172229No hitNo description
PROSITE profilePS5088815.288173224IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.22E-16173238IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.9E-10174225IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.0E-9179230IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 381 aa     Download sequence    Send to blast
MKQQTGETST NPNTNQMVDY MINTTQSLPP QPSLASNLFG PSSFDKLSFA DVMQFADFGP  60
KLALNQAKTC EEDSGMDPVY FLKFPVLNDK LQEDHHLSLM APQNFGENQE SYKGLSEDRI  120
SDDENRVDVE NNASVQLRFL GDNLEKSPLA EGGTSKSKKK RPRTLKTTEE VESQRMTHIA  180
VERNRRKQMN EHLRVLRSLM PSSYVQRGDQ ASIIGGAIEF VRELEQLLQC LESQKRRRLY  240
GDGQRPGETS LGVQATPQPP LIFPPVGVPN DHQAKLLEYE SGLQEETGES KSCLADVEVK  300
ILGFDALIKI LSRRRVGQLV KLIAALEELQ LNILHTNITT IEQTVLYSFN VKIGGEARVT  360
AKDIANAVQQ IFSFIHANSG I
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1174185RMTHIAVERNRR
2234238KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKZV34856.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011091423.10.0transcription factor FAMA isoform X3
SwissprotQ56YJ81e-136FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A068TT281e-174A0A068TT28_COFCA; Uncharacterized protein
STRINGcassava4.1_032429m1e-166(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA46572341
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-127bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]