PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus

Family

ERF

Protein Properties

Length: 255aa MW: 28701.7 Da PI: 7.943

Description

ERF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
HL.SW.v1.0.G034275.1	genome	HOPBASE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	58.2	2e-18	28	77	2	55
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 ++ GVr+++ +grWvAeI+d + ++ r +lg+f taeeAa+a+++a+ l+g HL.SW.v1.0.G034275.1 28 KFVGVRQRP-SGRWVAEIKDTT---QKIRMWLGTFETAEEAARAYDEAACLLRG 77 799****.7*****32...35********************99987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51032	19.585	28	85	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	6.0E-28	28	85	IPR001471	AP2/ERF domain
SMART	SM00380	8.3E-36	28	91	IPR001471	AP2/ERF domain
Pfam	PF00847	4.7E-13	28	77	IPR001471	AP2/ERF domain
CDD	cd00018	2.13E-32	28	84	No hit	No description
SuperFamily	SSF54171	2.88E-19	28	85	IPR016177	DNA-binding domain
PRINTS	PR00367	8.2E-8	29	40	IPR001471	AP2/ERF domain
PRINTS	PR00367	8.2E-8	51	67	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 255 aa Download sequence Send to blast
MEIQFQNSMI TKKKGRNKRN NKSSNKNKFV GVRQRPSGRW VAEIKDTTQK IRMWLGTFET 60 AEEAARAYDE AACLLRGSNT RTNFITHVSM DSPLASRIKN LLNNNNKKEK YLIMITMIDQ 120 NNKTLALALV IILVLVLAPQ QLLPVDAYKP DLSSFGFSQP SNNNNNLTST WGGGFDRFSF 180 GITGDGQLDL CKNSIENNVD DDGSEFLEFE RMKVERQISA SLYAMNGVQE YMEALHHDPV 240 DALWDLPPLC SLLC*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5wx9_A	6e-15	23	94	9	81	Ethylene-responsive transcription factor ERF096
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs) (PubMed:17449807, PubMed:17827349). Binds to the GCC-box (NF-responsive box) of ENOD11 promoter. Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349). Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation and maintenance, and nodule development. Necessary for NF-induced gene expression and spontaneous nodulation activated by CCAMK. Functions downstream of CCAMK to activate nodulation gene expression (PubMed:17449807). Involved in early stages of root nodule development. Functions redundantly with ERN2. Is essential with ERN2 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242). {ECO:0000269\|PubMed:17449807, ECO:0000269\|PubMed:17827349, ECO:0000269\|PubMed:23077241, ECO:0000269\|PubMed:27208242}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced in roots from 1 to 21 day after inoculation with Sinorhizobium meliloti (PubMed:17449807). Induced by Nod factors in root hairs (PubMed:17827349). {ECO:0000269\|PubMed:17449807, ECO:0000269\|PubMed:17827349}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015899372.1	4e-89	ethylene-responsive transcription factor RAP2-11-like
Swissprot	A2Q5W1	2e-86	ERN1_MEDTR; Ethylene-responsive transcription factor ERN1
TrEMBL	A0A2P5BK38	9e-89	A0A2P5BK38_PARAD; AP2/ERF transcription factor
STRING	VIT_08s0007g07250.t01	4e-85	(Vitis vinifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3341	30	69

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G19790.1	5e-37	related to AP2 11

Publications ? help Back to Top
Cerri MR, et al. Medicago truncatula ERN transcription factors: regulatory interplay with NSP1/NSP2 GRAS factors and expression dynamics throughout rhizobial infection. Plant Physiol., 2012. 160(4): p. 2155-72 [PMID:23077241] Tang H, et al. An improved genome release (version Mt4.0) for the model legume Medicago truncatula. BMC Genomics, 2014. 15: p. 312 [PMID:24767513] Cerri MR, et al. The Symbiosis-Related ERN Transcription Factors Act in Concert to Coordinate Rhizobial Host Root Infection. Plant Physiol., 2016. 171(2): p. 1037-54 [PMID:27208242]