PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus

Family

E2F/DP

Protein Properties

Length: 456aa MW: 50423.5 Da PI: 4.6935

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
HL.SW.v1.0.G027369.1	genome	HOPBASE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.6	1.9e-27	141	206	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg HL.SW.v1.0.G027369.1 141 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 206 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.1E-29	139	208	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	9.2E-35	141	206	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.18E-17	141	204	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.5E-24	143	206	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.66E-46	217	323	No hit	No description
SuperFamily	SSF144074	1.1E-32	218	323	No hit	No description
Pfam	PF16421	1.5E-32	222	321	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 456 aa Download sequence Send to blast
MSGSRAPNPS AQPSEQIRQP LKPQQLPFSS MKPPFSVPAD YHRFGPDPHR LTDHEAEGIV 60 VKPPLKRKGD MVDYEVESSD RGGSRFAEVV NSSLQTPVSV KAGKATKTSR LTKCSKARPQ 120 TPISNVGSPS GPNLTPAGPC RYDSSLGLLT KKFINLIKHA EDGILDLNKA ADTLEVQKRR 180 IYDITNVLEG IGLIEKKLKN RIQWKGLDVS RPGDADDNYA SLQAEVEKLS IEERTVDEQI 240 REMEERLRDL SEDENNQKWL FVTEDDIKGL PCFQNETLIA IKAPHGTTLE VPDPDEAADY 300 PQRRYRVVLR STMGPIDVYL VSQFEEKFEE IDGVQVPANF PSSSGVNENP ATTMATIDRG 360 KEDMKLQRQY DHEICADPTA AQDSVSGIMK IVPSDIDSEA DYWLLTDAAD VSITDMWNTE 420 HYPAVTVGTP KPQTPPSNPT EVPSTQSLDI NTSIN*

Sequence ? help Back to Top

Protein Sequence Length: 456 aa Download sequence Send to blast

MSGSRAPNPS AQPSEQIRQP LKPQQLPFSS MKPPFSVPAD YHRFGPDPHR LTDHEAEGIV  60
VKPPLKRKGD MVDYEVESSD RGGSRFAEVV NSSLQTPVSV KAGKATKTSR LTKCSKARPQ  120
TPISNVGSPS GPNLTPAGPC RYDSSLGLLT KKFINLIKHA EDGILDLNKA ADTLEVQKRR  180
IYDITNVLEG IGLIEKKLKN RIQWKGLDVS RPGDADDNYA SLQAEVEKLS IEERTVDEQI  240
REMEERLRDL SEDENNQKWL FVTEDDIKGL PCFQNETLIA IKAPHGTTLE VPDPDEAADY  300
PQRRYRVVLR STMGPIDVYL VSQFEEKFEE IDGVQVPANF PSSSGVNENP ATTMATIDRG  360
KEDMKLQRQY DHEICADPTA AQDSVSGIMK IVPSDIDSEA DYWLLTDAAD VSITDMWNTE  420
HYPAVTVGTP KPQTPPSNPT EVPSTQSLDI NTSIN*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	5e-27	136	207	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_007208279.2	0.0	transcription factor E2FB isoform X2
Swissprot	Q9FV71	1e-152	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A2P5CPL0	0.0	A0A2P5CPL0_TREOI; E2F Family
STRING	XP_008375957.1	0.0	(Malus domestica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-155	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]