PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G026215.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family E2F/DP
Protein Properties Length: 516aa    MW: 58700.8 Da    PI: 9.9794
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G026215.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP43.35.9e-141822123971
               E2F_TDP  39 vknkrRRiYDilNVLealnliekkekneirwkg 71 
                           v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  HL.SW.v1.0.G026215.1 182 V--ERRRIYDIVNVLESVGVLARKAKNQYTWKG 212
                           4..8***************************98 PP
2E2F_TDP75.26.7e-24282362171
               E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                           r+eksL lltq+f+kl+ +++ + ++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  HL.SW.v1.0.G026215.1 282 RREKSLALLTQNFVKLFVCTSVDLISLDEAAKLLLGDahnssIMRTKVRRLYDIANVLSSMNLIEKthtsdTRKPAFRWLG 362
                           689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM013728.8E-7135212IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.26E-9177213IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.3E-11180212IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.105.9E-13182214IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.2E-22278363IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.2E-31282362IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.0E-19284362IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.89E-13284363IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 516 aa     Download sequence    Send to blast
MFTLLRKAPL KKIPSQALKP IISIPCRSLS AMPPAEAAQV FAMTEIILKA APEALPETLL  60
NPTLDWTPDL IDKILKRLWN HGPKALQFFR VLDHHPNYAH SSSSFDHAID LAARLRDYKT  120
VWTLVARMRS RRLGPGPKTF AIIAERRDLK IVQWRRHRPL SPEPTPLNTT LIAGSRSLSA  180
WVERRRIYDI VNVLESVGVL ARKAKNQYTW KGFEAIPKAL KELKDEGLKE NFSSFDGNDD  240
AKVSDDEEDD ERISDPRTES QPDKLNPNLN LKSSASSKPE NRREKSLALL TQNFVKLFVC  300
TSVDLISLDE AAKLLLGDAH NSSIMRTKVR RLYDIANVLS SMNLIEKTHT SDTRKPAFRW  360
LGFEGRGRAN HNSSAHDSVV TESRKRSFGA DITNISFKRN KMDSLVGESL NMNFSKQKQV  420
KQESYVEEID RITFEEDSNE STKSYQFGPF APVTIARVGA SENNNPRKVH DWEKLASIYR  480
PQYQNQALND LFSHYMEAWK TWYSEVAEKN PIKIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A7e-3018235443228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015879579.11e-179E2F transcription factor-like E2FE isoform X2
RefseqXP_024924831.11e-179E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-115E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLW9SXR31e-175W9SXR3_9ROSA; E2F transcription factor-like E2FE
STRINGXP_010111971.11e-176(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-118DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]