PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

HL.SW.v1.0.G002769.1

Organism

Humulus lupulus

Taxonomic ID

3486

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus

Family

E2F/DP

Protein Properties

Length: 418aa MW: 46145.6 Da PI: 5.1471

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
HL.SW.v1.0.G002769.1	genome	HOPBASE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.4	2.1e-27	148	213	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg HL.SW.v1.0.G002769.1 148 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 213 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	2.6E-29	145	215	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	3.2E-17	148	211	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.0E-34	148	213	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.0E-24	150	213	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	5.49E-34	226	330	No hit	No description
CDD	cd14660	9.60E-48	226	330	No hit	No description
Pfam	PF16421	3.6E-33	229	328	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 418 aa Download sequence Send to blast
MSGGGRAHNR PAPPPPLASG GAQIVPPLRR HLAFTSTKPP FVPPDDYHRF SSDGRRAADQ 60 EPEAIVVRSP LLKRKNALEN NEVDHRDWAS SPGYINIVNN SPMQTPVSAK GGRTYNRSKG 120 SKANRSTPQT PVSNAGSPSP LTPAGSCRYD SSLGLLTKKF INLIKHAEDG ILDLNKAAET 180 LEVQKRRIYD ITNVLEGIGL IEKKLKNRIR WKGLDASRPG EVDGDISLLQ AEVENLNMEE 240 RSLDDRIREM QERLRDLSED ENNQKWLFVT EEDIKGLPCF HNETLIAIKA PHGTTLEVPD 300 PDEAVDYTQR RYRIILRSTM GPIDVYLVSQ FEEKFEEMNS AEPPANFPIA SSSGSSEPTA 360 TEVITVESNT GKEIEPQPQH DHQVCPDINA LQEFPGGMMK IVPSDVDAWG GSSECNE*

Sequence ? help Back to Top

Protein Sequence Length: 418 aa Download sequence Send to blast

MSGGGRAHNR PAPPPPLASG GAQIVPPLRR HLAFTSTKPP FVPPDDYHRF SSDGRRAADQ  60
EPEAIVVRSP LLKRKNALEN NEVDHRDWAS SPGYINIVNN SPMQTPVSAK GGRTYNRSKG  120
SKANRSTPQT PVSNAGSPSP LTPAGSCRYD SSLGLLTKKF INLIKHAEDG ILDLNKAAET  180
LEVQKRRIYD ITNVLEGIGL IEKKLKNRIR WKGLDASRPG EVDGDISLLQ AEVENLNMEE  240
RSLDDRIREM QERLRDLSED ENNQKWLFVT EEDIKGLPCF HNETLIAIKA PHGTTLEVPD  300
PDEAVDYTQR RYRIILRSTM GPIDVYLVSQ FEEKFEEMNS AEPPANFPIA SSSGSSEPTA  360
TEVITVESNT GKEIEPQPQH DHQVCPDINA LQEFPGGMMK IVPSDVDAWG GSSECNE*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-24	143	214	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015898822.1	0.0	transcription factor E2FA isoform X2
Refseq	XP_024922668.1	0.0	transcription factor E2FA isoform X3
Swissprot	Q9FNY0	1e-159	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2P5D9W8	0.0	A0A2P5D9W8_PARAD; E2F Family
STRING	EMJ05533	0.0	(Prunus persica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-164	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]