PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID EcC053464.10
Organism
Eucalyptus camaldulensis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Myrtales; Myrtaceae; Myrtoideae; Eucalypteae; Eucalyptus
Family bHLH
Protein Properties Length: 411aa    MW: 46588.5 Da    PI: 5.9283
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
EcC053464.10genomeECGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH27.36.4e-09204233130
                   CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC CS
           HLH   1 rrrahnerErrRRdriNsafeeLrellPka 30 
                   +r++h ++Er+RR+++N+ +  Lr+l+P +
  EcC053464.10 204 QRMTHIAVERNRRRQMNEHLRVLRSLMPGS 233
                   79**************************74 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474594.36E-8195235IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.18E-7202237No hitNo description
Gene3DG3DSA:4.10.280.101.0E-7202236IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088810.499203335IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.6E-6204233IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS516719.17337411IPR002912ACT domain
CDDcd048730.00323337401No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006412Biological Processtranslation
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0015934Cellular Componentlarge ribosomal subunit
GO:0003735Molecular Functionstructural constituent of ribosome
GO:0016597Molecular Functionamino acid binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 411 aa     Download sequence    Send to blast
GERRELLVLY YCCKHEQLLL QAIPDHNAFN DQHQHHHQFI RSQVGEIPVH HDGSGGGDNN  60
GMVDYMLSHP PQQGHQQLIS PLGFSGSGSL DKLSFADVMQ FADFGPKLAL NQASHNSEDE  120
AGIDPVCFLK FPVLNDNNDE RRIDDEDGVR EDQEATQFPD NASVQLHFLG EELQSNKSST  180
AAEASKNKRK RPRTSKTSEE VESQRMTHIA VERNRRRQMN EHLRVLRSLM PGSYVQRXXX  240
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX  300
NDPIKVPDFD TGLHEETAES KSCIADVEVK LLGFDAMIKI LSRRRPGQLI KTIAALEDLQ  360
LNILHTNITT IEQTVLYSFN VKVAGEARFT AEDIASSVQQ IFGFIHANSA I
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1204215RMTHIAVERNRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010026737.11e-145PREDICTED: transcription factor FAMA
RefseqXP_018716354.11e-145PREDICTED: transcription factor FAMA
SwissprotQ56YJ82e-53FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A059B1Q94e-91A0A059B1Q9_EUCGR; Uncharacterized protein
STRINGXP_010026737.11e-144(Eucalyptus grandis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM55482649
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.13e-53bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]