PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

E2F/DP

Protein Properties

Length: 284aa MW: 31915.3 Da PI: 10.3686

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cucsa.263480.1	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	68.7	7.2e-22	117	181	1	70
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 r+++sL lt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+N L+++ l kk kn+i+wk Cucsa.263480.1 117 RYDSSLSFLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNALKGIVLTGKKLKNRIQWK 181 6899****************************...99..**************************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.8E-22	114	181	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.7E-24	117	182	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	5.44E-13	117	180	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.9E-19	119	181	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 284 aa Download sequence Send to blast
MSSSRPPNSS GHLPHQITHS LKRQLPLSSM KPPFASPGDY HRFAPDSRLA DQEPDAIVLK 60 SPIREVVNRP HQTPVSVKGG KGGKSRLTKY SRSGPQTPIS NVGSSSTNNL TPAGPCRYDS 120 SLSFLTKKFI NLIKQAEDGI LDLNKAADTL EVQKRRIYDI TNALKGIVLT GKKLKNRIQW 180 KYNEKNIQQQ LILKYIESMM KEQSPSTPKS EGSTSKMKAK MFELSEEPKL NDKEDGEKNN 240 GRNKFKKVEM SVFNGEDPNS WLFHADRYFH IHKPNSWTDV ELV*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-21	112	181	2	72	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681842	4e-79	LN681842.1 Cucumis melo genomic scaffold, anchoredscaffold00022.
GenBank	LN713259	4e-79	LN713259.1 Cucumis melo genomic chromosome, chr_5.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008449589.1	1e-104	PREDICTED: transcription factor E2FB isoform X2
Swissprot	Q9FV71	1e-52	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A1S3BLR6	1e-102	A0A1S3BLR6_CUCME; transcription factor E2FB isoform X2
STRING	XP_004166944.1	1e-106	(Cucumis sativus)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	4e-51	E2F transcription factor 1

Link Out ? help Back to Top
Phytozome	Cucsa.263480.1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]