PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

ERF

Protein Properties

Length: 194aa MW: 21043.2 Da PI: 8.4728

Description

ERF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cucsa.122930.1	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	63.2	5.6e-20	19	69	2	56
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkklege 56 +y+GVr ++ +gr++AeIrdp++ ++r++lg+f taeeAa+a++aa+++++g+ Cucsa.122930.1 19 RYRGVRKRP-WGRYAAEIRDPRK---KTRVWLGTFNTAEEAARAYDAAAREFRGA 69 59*****.******843...6***********************985 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54171	4.71E-23	19	77	IPR016177	DNA-binding domain
PROSITE profile	PS51032	24.579	19	76	IPR001471	AP2/ERF domain
CDD	cd00018	1.02E-18	19	76	No hit	No description
Gene3D	G3DSA:3.30.730.10	1.4E-32	19	77	IPR001471	AP2/ERF domain
SMART	SM00380	1.4E-36	19	82	IPR001471	AP2/ERF domain
Pfam	PF00847	4.3E-14	19	68	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.7E-11	20	31	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.7E-11	42	58	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 194 aa Download sequence Send to blast
MAAGDRSTST TPPTSKEIRY RGVRKRPWGR YAAEIRDPRK KTRVWLGTFN TAEEAARAYD 60 AAAREFRGAN AKTNFPLQTD FLIVDNNNHS NFHKSACSTS PSHSSTVESS SPSPTPSDPY 120 LDGGIHPPGI SPPIFFFDAF AQAEKNISDF RRTVTAAVAG ASDSDSSSVG DFDTTRKSRP 180 LDFDLNLPAV EVV*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5wx9_A	9e-22	19	81	14	77	Ethylene-responsive transcription factor ERF096
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Acts as a transcriptional repressor. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways, and could also regulate other AtERFs. {ECO:0000269\|PubMed:10715325, ECO:0000269\|PubMed:11487705, ECO:0000269\|PubMed:9756931}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by jasmonate (JA) and by Alternaria brassicicola (locally and systemically), but only slightly by ethylene. Strong induction by wounding, cold or drought stress does not require EIN2, whereas induction by NaCl does. Transcripts accumulate in cycloheximide-treated plants, a protein synthesis inhibitor. Seems to not be influenced by exogenous abscisic acid (ABA), and heat stress. {ECO:0000269\|PubMed:10715325, ECO:0000269\|PubMed:12805630}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681862	0.0	LN681862.1 Cucumis melo genomic scaffold, anchoredscaffold00081.
GenBank	LN713261	0.0	LN713261.1 Cucumis melo genomic chromosome, chr_7.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004146050.1	1e-139	PREDICTED: ethylene-responsive transcription factor 4
Swissprot	O80340	5e-38	ERF78_ARATH; Ethylene-responsive transcription factor 4
TrEMBL	A0A0A0L4P1	1e-138	A0A0A0L4P1_CUCSA; Ethylene response factor 2
STRING	XP_004146050.1	1e-139	(Cucumis sativus)
STRING	XP_004162927.1	1e-139	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF330	34	189

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G15210.1	9e-23	ethylene responsive element binding factor 4

Link Out ? help Back to Top
Phytozome	Cucsa.122930.1
Entrez Gene	101213540

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Cao WH, et al. Modulation of ethylene responses affects plant salt-stress responses. Plant Physiol., 2007. 143(2): p. 707-19 [PMID:17189334] Ren Y, et al. An integrated genetic and cytogenetic map of the cucumber genome. PLoS ONE, 2009. 4(6): p. e5795 [PMID:19495411] Guo S, et al. Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types. BMC Genomics, 2010. 11: p. 384 [PMID:20565788] Li Z, et al. RNA-Seq improves annotation of protein-coding genes in the cucumber genome. BMC Genomics, 2011. 12: p. 540 [PMID:22047402] Lyons R, et al. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation. Sci Rep, 2013. 3: p. 2866 [PMID:24104185] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Gao S, et al. A cotton miRNA is involved in regulation of plant response to salt stress. Sci Rep, 2016. 6: p. 19736 [PMID:26813144] Zhou X, et al. The ERF11 Transcription Factor Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling. Plant Physiol., 2016. 171(4): p. 2760-70 [PMID:27255484] Liu W, et al. The ethylene response factor AtERF4 negatively regulates the iron deficiency response in Arabidopsis thaliana. PLoS ONE, 2017. 12(10): p. e0186580 [PMID:29045490]