PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis

Family

AP2

Protein Properties

Length: 461aa MW: 49930.2 Da PI: 8.1719

Description

AP2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cucsa.065430.1	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	47.4	4.9e-15	48	107	1	55
AP2 1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 s y+GV++++++gr++A+++d + g ++ ++++lg ++ +e+Aa+a++ a++k++g Cucsa.065430.1 48 SIYRGVTRHRWTGRYEAHLWDnSCRrEGqsRKgRQVYLGGYDKEEKAARAYDLAALKYWG 107 57*****************666664477446***********************98 PP
2	AP2	47.4	4.7e-15	152	201	3	55
AP2 3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 y+GV+++++ grW A+I + +k +lg+f t+eeAa+a++ a+ k++g Cucsa.065430.1 152 YRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFSTEEEAAEAYDIAAIKFRG 201 9*************988532...5**********************998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54171	2.09E-17	48	117	IPR016177	DNA-binding domain
Pfam	PF00847	5.6E-12	48	107	IPR001471	AP2/ERF domain
CDD	cd00018	3.21E-22	48	117	No hit	No description
SMART	SM00380	5.8E-30	49	121	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	6.0E-16	49	116	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	19.256	49	115	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.8E-6	50	61	IPR001471	AP2/ERF domain
CDD	cd00018	1.04E-23	150	211	No hit	No description
SuperFamily	SSF54171	4.18E-18	150	211	IPR016177	DNA-binding domain
SMART	SM00380	8.6E-33	151	215	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	2.4E-18	151	210	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	19.375	151	209	IPR001471	AP2/ERF domain
Pfam	PF00847	1.1E-9	152	201	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.8E-6	191	211	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000723	Biological Process	telomere maintenance
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007389	Biological Process	pattern specification process
GO:0010073	Biological Process	meristem maintenance
GO:0010449	Biological Process	root meristem growth
GO:0019827	Biological Process	stem cell population maintenance
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 461 aa Download sequence Send to blast
MGSGKPSTCE TTSTPDNNTT SNNSNNNSNT TLDVTPRRTL DTFGQRTSIY RGVTRHRWTG 60 RYEAHLWDNS CRREGQSRKG RQVYLGGYDK EEKAARAYDL AALKYWGTST TTNFPISNYE 120 KEVEEMKHMT RQEFVAAIRR KSSGFSRGAS MYRGVTRHHQ HGRWQARIGR VAGNKDLYLG 180 TFSTEEEAAE AYDIAAIKFR GLNAVTNFDM SRYDVKSILE SNTLPIGGGA AKRLKEAQAV 240 ESSRKRDEMI ALGSSSSSSS CFQYGTSSSS TTNSSHYPNL LQQPNLNIDH HHLQTQPLLS 300 LQNHHDISHY STHHPSSFHN PSSSYIHHSS DHSSYPNNNN NHPFYGAGYL HNHPALLHGM 360 INMSGGGGGA GAGGGGGGGG ASSLDTNNNT NALSHFESNS HGGGGYLGNA FGIGSASGST 420 AEEYALVKVD YDMPNSGGYG GWTGDSVQGS NAGVFSMWND *

Sequence ? help Back to Top

Protein Sequence Length: 461 aa Download sequence Send to blast

MGSGKPSTCE TTSTPDNNTT SNNSNNNSNT TLDVTPRRTL DTFGQRTSIY RGVTRHRWTG  60
RYEAHLWDNS CRREGQSRKG RQVYLGGYDK EEKAARAYDL AALKYWGTST TTNFPISNYE  120
KEVEEMKHMT RQEFVAAIRR KSSGFSRGAS MYRGVTRHHQ HGRWQARIGR VAGNKDLYLG  180
TFSTEEEAAE AYDIAAIKFR GLNAVTNFDM SRYDVKSILE SNTLPIGGGA AKRLKEAQAV  240
ESSRKRDEMI ALGSSSSSSS CFQYGTSSSS TTNSSHYPNL LQQPNLNIDH HHLQTQPLLS  300
LQNHHDISHY STHHPSSFHN PSSSYIHHSS DHSSYPNNNN NHPFYGAGYL HNHPALLHGM  360
INMSGGGGGA GAGGGGGGGG ASSLDTNNNT NALSHFESNS HGGGGYLGNA FGIGSASGST  420
AEEYALVKVD YDMPNSGGYG GWTGDSVQGS NAGVFSMWND *

Functional Description ? help Back to Top
Source	Description
UniProt	Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Master regulator of basal/root fate. Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis. Modulates the root polar auxin transport by regulating the distribution of PIN genes. Essential role in respecifying pattern and polarity in damaged roots. Direct target of the transcriptional corepressor TPL. Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs). {ECO:0000250, ECO:0000269\|PubMed:15454085, ECO:0000269\|PubMed:15635403, ECO:0000269\|PubMed:16424342, ECO:0000269\|PubMed:20190735}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By auxin accumulation. {ECO:0000269\|PubMed:15454085}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681842	0.0	LN681842.1 Cucumis melo genomic scaffold, anchoredscaffold00022.
GenBank	LN713259	0.0	LN713259.1 Cucumis melo genomic chromosome, chr_5.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011653587.1	0.0	PREDICTED: AP2-like ethylene-responsive transcription factor PLT2
Swissprot	Q5YGP7	0.0	PLET2_ARATH; AP2-like ethylene-responsive transcription factor PLT2
TrEMBL	A0A0A0KX09	0.0	A0A0A0KX09_CUCSA; Uncharacterized protein
STRING	XP_004142127.1	0.0	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4942	31	52

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G51190.1	1e-172	AP2 family protein

Link Out ? help Back to Top
Phytozome	Cucsa.065430.1
Entrez Gene	101207097

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Ren Y, et al. An integrated genetic and cytogenetic map of the cucumber genome. PLoS ONE, 2009. 4(6): p. e5795 [PMID:19495411] Guo S, et al. Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types. BMC Genomics, 2010. 11: p. 384 [PMID:20565788] Li Z, et al. RNA-Seq improves annotation of protein-coding genes in the cucumber genome. BMC Genomics, 2011. 12: p. 540 [PMID:22047402] Lee DK,Sieburth LE The bps signal: embryonic arrest from an auxin-independent mechanism in bypass triple mutants. Plant Signal Behav, 2012. 7(6): p. 698-700 [PMID:22580686] Hong LW,Yan DW,Liu WC,Chen HG,Lu YT TIME FOR COFFEE controls root meristem size by changes in auxin accumulation in Arabidopsis. J. Exp. Bot., 2014. 65(1): p. 275-86 [PMID:24277277] Tian H,Jia Y,Niu T,Yu Q,Ding Z The key players of the primary root growth and development also function in lateral roots in Arabidopsis. Plant Cell Rep., 2014. 33(5): p. 745-53 [PMID:24504658] Zhao Q, et al. Sulfur nutrient availability regulates root elongation by affecting root indole-3-acetic acid levels and the stem cell niche. J Integr Plant Biol, 2014. 56(12): p. 1151-63 [PMID:24831283] Huang JB, et al. ROP3 GTPase contributes to polar auxin transport and auxin responses and is important for embryogenesis and seedling growth in Arabidopsis. Plant Cell, 2014. 26(9): p. 3501-18 [PMID:25217509] Yang S, et al. The Arabidopsis SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA Targets Directly to PINs and Is Required for Root Stem Cell Niche Maintenance. Plant Cell, 2015. 27(6): p. 1670-80 [PMID:25991732] Jia Y, et al. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. J. Exp. Bot., 2015. 66(15): p. 4631-42 [PMID:25998905] Zhang M, et al. A tetratricopeptide repeat domain-containing protein SSR1 located in mitochondria is involved in root development and auxin polar transport in Arabidopsis. Plant J., 2015. 83(4): p. 582-99 [PMID:26072661] Shinohara H,Mori A,Yasue N,Sumida K,Matsubayashi Y Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A., 2016. 113(14): p. 3897-902 [PMID:27001831] Ou Y, et al. RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Res., 2016. 26(6): p. 686-98 [PMID:27229312] Santuari L, et al. The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots. Plant Cell, 2016. 28(12): p. 2937-2951 [PMID:27920338] Promchuea S,Zhu Y,Chen Z,Zhang J,Gong Z ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis . J Integr Plant Biol, 2017. 59(1): p. 30-43 [PMID:28074634] Du Y,Scheres B PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth. Proc. Natl. Acad. Sci. U.S.A., 2017. 114(44): p. 11709-11714 [PMID:29078398] Bustillo-Avendaño E, et al. Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis. Plant Physiol., 2018. 176(2): p. 1709-1727 [PMID:29233938]