PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

CCG008350.3

Organism

Populus euphratica

Taxonomic ID

75702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus

Family

E2F/DP

Protein Properties

Length: 474aa MW: 52243.8 Da PI: 6.3842

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
CCG008350.3	genome	LZU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	82.1	4.7e-26	146	210	1	70
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 r+++sL+llt++f++l++++++gi++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn+irwk CCG008350.3 146 RYDSSLGLLTKRFVDLFKNAHDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWK 210 6899****************************...99..**************************7 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	2.5E-27	143	210	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.1E-33	146	211	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.39E-17	146	209	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.3E-23	148	210	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	3.14E-30	244	347	No hit	No description
Pfam	PF16421	5.8E-32	246	345	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	8.48E-47	246	347	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 474 aa Download sequence Send to blast
MSGGAKASPR PAATAPPSGP ILPPLARHLA FATMKPPFLP PDDYHRFSSP STSRVAADRD 60 AEAIVVRSPK LKRKSGLADN GVSSSNHVSS PGCINISNSP FRTPASAKGG RAHNNSKTSK 120 GNGAGPQTPV SKADCSSPLT PAGSCRYDSS LGLLTKRFVD LFKNAHDGIL DLNNAAETLE 180 VQKRRIYDIT NVLEGIGLIE KTLKNRIRWK HPKHMGTRIG INLIEWLTRG IDASRPRQVE 240 GDATLLQEEI EKLTMEEHKL DDQIREMQER LRDMSEQENN QKWLFVTEED IKSLPCFLNE 300 TLIAIKAPHG TTLEVLDPDE AVDCQQRRYR IILRSSMGPI DVYLVSQFEE MNSVDASAFP 360 HASSSASHGN PVTEMTTGVR TEKRADPLAQ QVPTTFSDPN ATQDLGGMMK IVPSDINNDS 420 DYWLLSDADI SITDMWKTDC GSFFGFYALL EPDTELVRNY GGETRKQAFE YHPG

Sequence ? help Back to Top

Protein Sequence Length: 474 aa Download sequence Send to blast

MSGGAKASPR PAATAPPSGP ILPPLARHLA FATMKPPFLP PDDYHRFSSP STSRVAADRD  60
AEAIVVRSPK LKRKSGLADN GVSSSNHVSS PGCINISNSP FRTPASAKGG RAHNNSKTSK  120
GNGAGPQTPV SKADCSSPLT PAGSCRYDSS LGLLTKRFVD LFKNAHDGIL DLNNAAETLE  180
VQKRRIYDIT NVLEGIGLIE KTLKNRIRWK HPKHMGTRIG INLIEWLTRG IDASRPRQVE  240
GDATLLQEEI EKLTMEEHKL DDQIREMQER LRDMSEQENN QKWLFVTEED IKSLPCFLNE  300
TLIAIKAPHG TTLEVLDPDE AVDCQQRRYR IILRSSMGPI DVYLVSQFEE MNSVDASAFP  360
HASSSASHGN PVTEMTTGVR TEKRADPLAQ QVPTTFSDPN ATQDLGGMMK IVPSDINNDS  420
DYWLLSDADI SITDMWKTDC GSFFGFYALL EPDTELVRNY GGETRKQAFE YHPG

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	4e-21	141	210	2	72	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011044036.1	0.0	PREDICTED: transcription factor E2FA-like isoform X3
Swissprot	Q9FNY0	1e-144	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A2K1XC41	0.0	A0A2K1XC41_POPTR; Uncharacterized protein
STRING	POPTR_0016s07310.1	0.0	(Populus trichocarpa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-143	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]