PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Bradi4g42050.1.p
Common NameBRADI_4g42050, LOC100839650
Organism
Brachypodium distachyon
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Brachypodieae; Brachypodium
Family E2F/DP
Protein Properties Length: 450aa    MW: 48715.4 Da    PI: 4.392
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Bradi4g42050.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP832.5e-26134199171
           E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                       r+++sL+llt+kfl+ll+ ++ g+v+ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Bradi4g42050.1.p 134 RYDSSLGLLTKKFLNLLKGAPGGMVDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNNIRWKG 199
                       6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.9E-28132200IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.77E-16134197IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-34134199IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.0E-23136199IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.82E-49210316No hitNo description
SuperFamilySSF1440742.17E-32211316No hitNo description
PfamPF164212.0E-33215314IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 450 aa     Download sequence    Send to blast
MAATAGAGTS SEGAARVLLQ RYQPFGSPPG EYHHFGPADG SGAGAGEMTE AIVLRTPLKR  60
KHNREDNGVA ESNDWMMSPG YANAASSPVP TPPSGKGSKH STKLKSAKGQ KSCSQAPLFS  120
GSPGNPATPV GGCRYDSSLG LLTKKFLNLL KGAPGGMVDL NNAAETLEVQ KRRIYDITNV  180
LEGIGLIEKK LKNNIRWKGI DDSRPGEVSD DMSILQGDIE ALTLQEHSVD EQISEMRDKL  240
RELTEDENNQ KWLYVTEDDI KSLSCFQNQT LIAIKAPHGT TLEVPDPDEV NDYPQRRYRI  300
VLRSTMGPID VYLVSQFEEM SGMETPPRPA QTISTNSLEN PRTPLAAGSN KDAEMQLNIQ  360
DEPIIPPDAP TSSQDIGGMM KIVPSDLDAD ADYWLLSDTG VSITDMWKTA PEVEWDGMDI  420
NADDFLEVST PQQQGQLPSD IADLPSCIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-22126200274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapBradi4g42050.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003578886.10.0transcription factor E2FA isoform X1
SwissprotQ9FNY01e-123E2FA_ARATH; Transcription factor E2FA
TrEMBLI1IU740.0I1IU74_BRADI; Uncharacterized protein
STRINGBRADI4G42050.10.0(Brachypodium distachyon)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Representative plantOGRP12251749
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-116E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]