PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT4G11660.1

Common Name

AT-HSFB2B, HSF11, HSF7, HSFB2B, T5C23.90

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

HSF

Protein Properties

Length: 377aa MW: 39705.1 Da PI: 4.6287

Description

HSF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G11660.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HSF_DNA-bind	115.5	3.3e-36	60	152	2	103
HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXXX CS HSF_DNA-bind 2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellekik 98 Fl+k+y+++ed+ ++elisw+e+g++f+v+ + efa+++LpkyFkh+nf+SFvRQLn+YgF+kv ++ weF+++ Fk+g+k ll++i+ AT4G11660.1 60 FLTKTYQLVEDPVYDELISWNEDGTTFIVWRPAEFARDLLPKYFKHNNFSSFVRQLNTYGFRKVVPDR---------WEFSNDCFKRGEKILLRDIQ 147 9***************************************************************99.........**************** PP XXXXX CS HSF_DNA-bind 99 rkkse 103 r+k + AT4G11660.1 148 RRKIS 152 865 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00415	1.6E-58	56	149	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Gene3D	G3DSA:1.10.10.10	9.4E-38	57	149	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.27E-34	57	149	IPR011991	Winged helix-turn-helix DNA-binding domain
PRINTS	PR00056	3.5E-20	60	83	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Pfam	PF00447	7.7E-32	60	149	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	3.5E-20	98	110	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PROSITE pattern	PS00434	0	99	123	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	3.5E-20	111	123	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Gene3D	G3DSA:1.20.5.170	8.1E-4	228	255	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010200	Biological Process	response to chitin
GO:0045892	Biological Process	negative regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000084	anatomy	plant sperm cell
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001017	developmental stage	M germinated pollen stage
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 377 aa Download sequence Send to blast
MPGEQTGETP TVAGVGGGGA GCSAGNSGGS SGCGAGGGGG GSGGGGGGGG DSQRSIPTPF 60 LTKTYQLVED PVYDELISWN EDGTTFIVWR PAEFARDLLP KYFKHNNFSS FVRQLNTYGF 120 RKVVPDRWEF SNDCFKRGEK ILLRDIQRRK ISQPAMAAAA AAAAAAVAAS AVTVAAVPVV 180 AHIVSPSNSG EEQVISSNSS PAAAAAAIGG VVGGGSLQRT TSCTTAPELV EENERLRKDN 240 ERLRKEMTKL KGLYANIYTL MANFTPGQED CAHLLPEGKP LDLLPERQEM SEAIMASEIE 300 TGIGLKLGED LTPRLFGVSI GVKRARREEE LGAAEEEDDD RREAAAQEGE QSSDVKAEPM 360 EENNSGNHNG SWLELGK

Sequence ? help Back to Top

Protein Sequence Length: 377 aa Download sequence Send to blast

MPGEQTGETP TVAGVGGGGA GCSAGNSGGS SGCGAGGGGG GSGGGGGGGG DSQRSIPTPF  60
LTKTYQLVED PVYDELISWN EDGTTFIVWR PAEFARDLLP KYFKHNNFSS FVRQLNTYGF  120
RKVVPDRWEF SNDCFKRGEK ILLRDIQRRK ISQPAMAAAA AAAAAAVAAS AVTVAAVPVV  180
AHIVSPSNSG EEQVISSNSS PAAAAAAIGG VVGGGSLQRT TSCTTAPELV EENERLRKDN  240
ERLRKEMTKL KGLYANIYTL MANFTPGQED CAHLLPEGKP LDLLPERQEM SEAIMASEIE  300
TGIGLKLGED LTPRLFGVSI GVKRARREEE LGAAEEEDDD RREAAAQEGE QSSDVKAEPM  360
EENNSGNHNG SWLELGK

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5d5u_B	1e-27	29	149	1	129	Heat shock factor protein 1
5d5v_B	1e-27	29	149	1	129	Heat shock factor protein 1
5d5v_D	1e-27	29	149	1	129	Heat shock factor protein 1
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.24995	0.0	root\| seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	145340115	0.0
Genevisible	254878_at	0.0
Expression Atlas	AT4G11660	-
AtGenExpress	AT4G11660	-
ATTED-II	AT4G11660	-

Functional Description ? help Back to Top
Source	Description
TAIR	member of Heat Stress Transcription Factor (Hsf) family
UniProt	Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Function -- GeneRIF ? help Back to Top
Data suggest that HsfB1 and HsfB2b may be involved in complex regulatory networks, which are linked to other stress responses and signaling processes. [PMID: 19945192] These data indicate that HsfB1 and HsfB2b suppress the general heat shock response under non-heat-stress conditions and in the attenuating period. [PMID: 21908690] The constitutive expression of HsfB2b leads to severely reduced levels of the PRR7 transcript and late flowering and elongated hypocotyls. [PMID: 25352668]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00432	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G11660.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Interaction ? help Back to Top
Source	Intact With
BioGRID	AT4G11660

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G11660

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY093206	0.0	AY093206.1 Arabidopsis thaliana heat shock transcription factor-like protein (At4g11660) mRNA, complete cds.
GenBank	BT008471	0.0	BT008471.1 Arabidopsis thaliana At4g11660 gene, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_192903.1	0.0	winged-helix DNA-binding transcription factor family protein
Swissprot	Q9T0D3	0.0	HFB2B_ARATH; Heat stress transcription factor B-2b
TrEMBL	A0A178UZH9	0.0	A0A178UZH9_ARATH; HSFB2B
STRING	AT4G11660.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM965	28	111
Representative plant	OGRP96	17	233

Link Out ? help Back to Top
Phytozome	AT4G11660.1
Entrez Gene	826771
iHOP	AT4G11660
wikigenes	AT4G11660

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Nover L, et al. Arabidopsis and the heat stress transcription factor world: how many heat stress transcription factors do we need? Cell Stress Chaperones, 2001. 6(3): p. 177-89 [PMID:11599559] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Lohmann C,Eggers-Schumacher G,Wunderlich M,Sch Two different heat shock transcription factors regulate immediate early expression of stress genes in Arabidopsis. Mol. Genet. Genomics, 2004. 271(1): p. 11-21 [PMID:14655047] Vanderauwera S, et al. Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis. Plant Physiol., 2005. 139(2): p. 806-21 [PMID:16183842] Charng YY, et al. A heat-inducible transcription factor, HsfA2, is required for extension of acquired thermotolerance in Arabidopsis. Plant Physiol., 2007. 143(1): p. 251-62 [PMID:17085506] Libault M,Wan J,Czechowski T,Udvardi M,Stacey G Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor. Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11 [PMID:17722694] Guo J, et al. Genome-wide analysis of heat shock transcription factor families in rice and Arabidopsis. J Genet Genomics, 2008. 35(2): p. 105-18 [PMID:18407058] Krishnaswamy SS, et al. Transcriptional profiling of pea ABR17 mediated changes in gene expression in Arabidopsis thaliana. BMC Plant Biol., 2008. 8: p. 91 [PMID:18783601] Ikeda M,Ohme-Takagi M A novel group of transcriptional repressors in Arabidopsis. Plant Cell Physiol., 2009. 50(5): p. 970-5 [PMID:19324928] Kumar M, et al. Heat shock factors HsfB1 and HsfB2b are involved in the regulation of Pdf1.2 expression and pathogen resistance in Arabidopsis. Mol Plant, 2009. 2(1): p. 152-65 [PMID:19529832] Li M, et al. Detection of in vivo interactions between Arabidopsis class A-HSFs, using a novel BiFC fragment, and identification of novel class B-HSF interacting proteins. Eur. J. Cell Biol., 2010 Feb-Mar. 89(2-3): p. 126-32 [PMID:19945192] Ikeda M,Mitsuda N,Ohme-Takagi M Arabidopsis HsfB1 and HsfB2b act as repressors of the expression of heat-inducible Hsfs but positively regulate the acquired thermotolerance. Plant Physiol., 2011. 157(3): p. 1243-54 [PMID:21908690] Causier B,Ashworth M,Guo W,Davies B The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol., 2012. 158(1): p. 423-38 [PMID:22065421] Zhu X,Thalor SK,Takahashi Y,Berberich T,Kusano T An inhibitory effect of the sequence-conserved upstream open-reading frame on the translation of the main open-reading frame of HsfB1 transcripts in Arabidopsis. Plant Cell Environ., 2012. 35(11): p. 2014-30 [PMID:22571635] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Kolmos E,Chow BY,Pruneda-Paz JL,Kay SA HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock. Proc. Natl. Acad. Sci. U.S.A., 2014. 111(45): p. 16172-7 [PMID:25352668]