PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Trifolium medium
WRKY Family
Species TF ID Description
MCH82883.1WRKY family protein
MCH87742.1WRKY family protein
MCH89171.1WRKY family protein
MCH91184.1WRKY family protein
MCH92267.1WRKY family protein
MCH93897.1WRKY family protein
MCH96058.1WRKY family protein
MCH99709.1WRKY family protein
MCI00083.1WRKY family protein
MCI01625.1WRKY family protein
MCI02208.1WRKY family protein
MCI03426.1WRKY family protein
MCI05766.1WRKY family protein
MCI06141.1WRKY family protein
MCI12112.1WRKY family protein
MCI12120.1WRKY family protein
MCI16997.1WRKY family protein
MCI17424.1WRKY family protein
MCI17638.1WRKY family protein
MCI17999.1WRKY family protein
MCI18083.1WRKY family protein
MCI19255.1WRKY family protein
MCI20193.1WRKY family protein
MCI20306.1WRKY family protein
MCI20371.1WRKY family protein
MCI22546.1WRKY family protein
MCI26194.1WRKY family protein
MCI28993.1WRKY family protein
MCI29493.1WRKY family protein
MCI29829.1WRKY family protein
MCI32848.1WRKY family protein
MCI42363.1WRKY family protein
MCI42512.1WRKY family protein
MCI60384.1WRKY family protein
MCI62231.1WRKY family protein
MCI71109.1WRKY family protein
MCI71463.1WRKY family protein
MCI72290.1WRKY family protein
MCI75054.1WRKY family protein
MCI83264.1WRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701