PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Triticum dicoccoides
GeBP Family
Species TF ID Description
TRIDC2AG019090.1GeBP family protein
TRIDC2AG019090.2GeBP family protein
TRIDC2AG019090.3GeBP family protein
TRIDC2AG019090.4GeBP family protein
TRIDC2AG064810.2GeBP family protein
TRIDC2BG022850.1GeBP family protein
TRIDC2BG022850.2GeBP family protein
TRIDC2BG022850.3GeBP family protein
TRIDC2BG022850.4GeBP family protein
TRIDC3AG004810.1GeBP family protein
TRIDC3AG004810.2GeBP family protein
TRIDC3BG027380.2GeBP family protein
TRIDC3BG027380.3GeBP family protein
TRIDC4AG019550.1GeBP family protein
TRIDC4AG042060.1GeBP family protein
TRIDC4AG042060.2GeBP family protein
TRIDC4AG042060.3GeBP family protein
TRIDC4AG042060.4GeBP family protein
TRIDC4BG006920.2GeBP family protein
TRIDC4BG006920.3GeBP family protein
TRIDC4BG006920.4GeBP family protein
TRIDC4BG026900.1GeBP family protein
TRIDC4BG026900.2GeBP family protein
TRIDC5AG037140.1GeBP family protein
TRIDC5AG037140.2GeBP family protein
TRIDC5BG039120.1GeBP family protein
TRIDC5BG039120.2GeBP family protein
TRIDC6AG048840.1GeBP family protein
TRIDC6AG049350.1GeBP family protein
TRIDC6BG057130.7GeBP family protein
TRIDC6BG057130.8GeBP family protein
TRIDC6BG057810.1GeBP family protein
TRIDC7AG021020.1GeBP family protein
TRIDC7AG021020.2GeBP family protein
TRIDC7AG025300.1GeBP family protein
TRIDC7BG011070.1GeBP family protein
TRIDC7BG011070.2GeBP family protein
TRIDC7BG011070.3GeBP family protein
TRIDC7BG015530.1GeBP family protein
GeBP Family Introduction

Understanding the role of transcription factors (TFs) is essential in reconstructing developmental regulatory networks. The plant-specific GeBP TF family of Arabidopsis thaliana (Arabidopsis) comprises 21 members, all of unknown function. A subset of four members, the founding member GeBP and GeBP-like proteins (GPL) 1, 2, and 3, shares a conserved C-terminal domain. Here we report that GeBP/GPL genes represent a newly defined class of leucine-zipper (Leu-zipper) TFs and that they play a redundant role in cytokinin hormone pathway regulation. Specifically, we demonstrate using yeast, in vitro, and split-yellow fluorescent protein in planta assays that GeBP/GPL proteins form homo- and heterodimers through a noncanonical Leu-zipper motif located in the C-terminal domain. A triple loss-of-function mutant of the three most closely related genes gebp gpl1 gpl2 shows a reduced sensitivity to exogenous cytokinins in a subset of cytokinin responses such as senescence and growth, whereas root inhibition is not affected. We find that transcript levels of type-A cytokinin response genes, which are involved in the negative feedback regulation of cytokinin signaling, are higher in the triple mutant. Using a GPL version that acts as a constitutive transcriptional activator, we show that the regulation of Arabidopsis response regulators (ARRs) is mediated by at least one additional, as yet unknown, repressor acting genetically downstream in the GeBP/GPL pathway. Our results indicate that GeBP/GPL genes encode a new class of unconventional Leu-zipper TF proteins and suggest that their role in the cytokinin pathway is to antagonize the negative feedback regulation on ARR genes to trigger the cytokinin response.

Chevalier F, Perazza D, Laporte F, Le Henanff G, Hornitschek P, Bonneville JM, Herzog M, Vachon G
GeBP and GeBP-Like Proteins Are Noncanonical Leucine-Zipper Transcription Factors That Regulate Cytokinin Response in Arabidopsis
Plant Physiol. 2008 Mar;146(3):1142-54.
PMID: 18162594