PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Salvia splendens
MIKC_MADS Family
Species TF ID Description
TEY11070.1MIKC_MADS family protein
TEY12168.1MIKC_MADS family protein
TEY12334.1MIKC_MADS family protein
TEY13293.1MIKC_MADS family protein
TEY14912.1MIKC_MADS family protein
TEY15104.1MIKC_MADS family protein
TEY15637.1MIKC_MADS family protein
TEY16566.1MIKC_MADS family protein
TEY17402.1MIKC_MADS family protein
TEY17587.1MIKC_MADS family protein
TEY17752.1MIKC_MADS family protein
TEY18760.1MIKC_MADS family protein
TEY19917.1MIKC_MADS family protein
TEY19920.1MIKC_MADS family protein
TEY21174.1MIKC_MADS family protein
TEY23388.1MIKC_MADS family protein
TEY24665.1MIKC_MADS family protein
TEY25348.1MIKC_MADS family protein
TEY25349.1MIKC_MADS family protein
TEY25350.1MIKC_MADS family protein
TEY26428.1MIKC_MADS family protein
TEY26853.1MIKC_MADS family protein
TEY27274.1MIKC_MADS family protein
TEY28322.1MIKC_MADS family protein
TEY28915.1MIKC_MADS family protein
TEY30436.1MIKC_MADS family protein
TEY30634.1MIKC_MADS family protein
TEY31613.1MIKC_MADS family protein
TEY31633.1MIKC_MADS family protein
TEY37037.1MIKC_MADS family protein
TEY37340.1MIKC_MADS family protein
TEY37495.1MIKC_MADS family protein
TEY38058.1MIKC_MADS family protein
TEY38245.1MIKC_MADS family protein
TEY41530.1MIKC_MADS family protein
TEY42574.1MIKC_MADS family protein
TEY45609.1MIKC_MADS family protein
TEY46662.1MIKC_MADS family protein
TEY47158.1MIKC_MADS family protein
TEY47519.1MIKC_MADS family protein
TEY48512.1MIKC_MADS family protein
TEY49559.1MIKC_MADS family protein
TEY52209.1MIKC_MADS family protein
TEY52784.1MIKC_MADS family protein
TEY55076.1MIKC_MADS family protein
TEY55772.1MIKC_MADS family protein
TEY57187.1MIKC_MADS family protein
TEY57895.1MIKC_MADS family protein
TEY59025.1MIKC_MADS family protein
TEY61883.1MIKC_MADS family protein
TEY63027.1MIKC_MADS family protein
TEY63482.1MIKC_MADS family protein
TEY66630.1MIKC_MADS family protein
TEY68685.1MIKC_MADS family protein
TEY69755.1MIKC_MADS family protein
TEY71070.1MIKC_MADS family protein
TEY72684.1MIKC_MADS family protein
TEY78096.1MIKC_MADS family protein
TEY81489.1MIKC_MADS family protein
TEY82018.1MIKC_MADS family protein
TEY82149.1MIKC_MADS family protein
TEY84380.1MIKC_MADS family protein
TEY86245.1MIKC_MADS family protein
TEY86861.1MIKC_MADS family protein
TEY86862.1MIKC_MADS family protein
TEY87687.1MIKC_MADS family protein
TEY87888.1MIKC_MADS family protein
TEY90376.1MIKC_MADS family protein
TEY90561.1MIKC_MADS family protein
TEY90569.1MIKC_MADS family protein
TEY91379.1MIKC_MADS family protein
TEY91389.1MIKC_MADS family protein
TEY92460.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513