PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Rubus occidentalis
HD-ZIP Family
Species TF ID Description
Ro01_G00989HD-ZIP family protein
Ro01_G11169HD-ZIP family protein
Ro01_G12235HD-ZIP family protein
Ro01_G18760HD-ZIP family protein
Ro01_G30012HD-ZIP family protein
Ro02_G00676HD-ZIP family protein
Ro02_G04430HD-ZIP family protein
Ro03_G07450HD-ZIP family protein
Ro03_G10075HD-ZIP family protein
Ro03_G10561HD-ZIP family protein
Ro03_G16159HD-ZIP family protein
Ro03_G27758HD-ZIP family protein
Ro03_G31799HD-ZIP family protein
Ro03_G32190HD-ZIP family protein
Ro03_G32299HD-ZIP family protein
Ro04_G00095HD-ZIP family protein
Ro04_G00128HD-ZIP family protein
Ro04_G00171HD-ZIP family protein
Ro04_G17930HD-ZIP family protein
Ro04_G26212HD-ZIP family protein
Ro05_G03671HD-ZIP family protein
Ro05_G11760HD-ZIP family protein
Ro05_G13831HD-ZIP family protein
Ro05_G16445HD-ZIP family protein
Ro05_G24582HD-ZIP family protein
Ro05_G31562HD-ZIP family protein
Ro06_G06767HD-ZIP family protein
Ro06_G12392HD-ZIP family protein
Ro06_G15216HD-ZIP family protein
Ro06_G16323HD-ZIP family protein
Ro06_G19235HD-ZIP family protein
Ro06_G25215HD-ZIP family protein
Ro06_G28033HD-ZIP family protein
Ro06_G28194HD-ZIP family protein
Ro06_G29363HD-ZIP family protein
Ro06_G29434HD-ZIP family protein
Ro07_G06913HD-ZIP family protein
Ro07_G07895HD-ZIP family protein
Ro07_G09468HD-ZIP family protein
Ro07_G17544HD-ZIP family protein
Ro07_G24009HD-ZIP family protein
Ro07_G33618HD-ZIP family protein
Ro07_G33754HD-ZIP family protein
Ro07_G33792HD-ZIP family protein
Ro07_G34766HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401