PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Quercus suber
Species TF ID Description
XP_023872295.1MIKC_MADS family protein
XP_023872513.1MIKC_MADS family protein
XP_023872514.1MIKC_MADS family protein
XP_023872515.1MIKC_MADS family protein
XP_023872516.1MIKC_MADS family protein
XP_023872547.1MIKC_MADS family protein
XP_023872548.1MIKC_MADS family protein
XP_023872549.1MIKC_MADS family protein
XP_023876386.1MIKC_MADS family protein
XP_023876869.1MIKC_MADS family protein
XP_023878588.1MIKC_MADS family protein
XP_023878589.1MIKC_MADS family protein
XP_023880231.1MIKC_MADS family protein
XP_023887186.1MIKC_MADS family protein
XP_023887238.1MIKC_MADS family protein
XP_023887239.1MIKC_MADS family protein
XP_023887343.1MIKC_MADS family protein
XP_023887353.1MIKC_MADS family protein
XP_023887393.1MIKC_MADS family protein
XP_023888157.1MIKC_MADS family protein
XP_023894512.1MIKC_MADS family protein
XP_023894513.1MIKC_MADS family protein
XP_023894634.1MIKC_MADS family protein
XP_023894705.1MIKC_MADS family protein
XP_023894765.1MIKC_MADS family protein
XP_023894825.1MIKC_MADS family protein
XP_023894891.1MIKC_MADS family protein
XP_023895429.1MIKC_MADS family protein
XP_023899435.1MIKC_MADS family protein
XP_023900830.1MIKC_MADS family protein
XP_023900831.1MIKC_MADS family protein
XP_023900833.1MIKC_MADS family protein
XP_023900834.1MIKC_MADS family protein
XP_023901996.1MIKC_MADS family protein
XP_023903253.1MIKC_MADS family protein
XP_023903430.1MIKC_MADS family protein
XP_023905937.1MIKC_MADS family protein
XP_023906595.1MIKC_MADS family protein
XP_023906601.1MIKC_MADS family protein
XP_023906610.1MIKC_MADS family protein
XP_023906617.1MIKC_MADS family protein
XP_023907205.1MIKC_MADS family protein
XP_023907206.1MIKC_MADS family protein
XP_023907207.1MIKC_MADS family protein
XP_023907208.1MIKC_MADS family protein
XP_023910685.1MIKC_MADS family protein
XP_023911257.1MIKC_MADS family protein
XP_023911258.1MIKC_MADS family protein
XP_023911967.1MIKC_MADS family protein
XP_023912243.1MIKC_MADS family protein
XP_023912244.1MIKC_MADS family protein
XP_023914605.1MIKC_MADS family protein
XP_023914833.1MIKC_MADS family protein
XP_023914834.1MIKC_MADS family protein
XP_023914914.1MIKC_MADS family protein
XP_023914921.1MIKC_MADS family protein
XP_023914928.1MIKC_MADS family protein
XP_023914935.1MIKC_MADS family protein
XP_023914944.1MIKC_MADS family protein
XP_023914975.1MIKC_MADS family protein
XP_023916617.1MIKC_MADS family protein
XP_023917960.1MIKC_MADS family protein
XP_023919877.1MIKC_MADS family protein
XP_023919884.1MIKC_MADS family protein
XP_023919892.1MIKC_MADS family protein
XP_023919899.1MIKC_MADS family protein
XP_023922130.1MIKC_MADS family protein
XP_023922131.1MIKC_MADS family protein
XP_023923299.1MIKC_MADS family protein
XP_023924416.1MIKC_MADS family protein
XP_023925149.1MIKC_MADS family protein
XP_023927341.1MIKC_MADS family protein
XP_023928415.1MIKC_MADS family protein
XP_023928416.1MIKC_MADS family protein
XP_023928490.1MIKC_MADS family protein
XP_023928492.1MIKC_MADS family protein
XP_023928493.1MIKC_MADS family protein
XP_023928494.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513