PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Pyrus communis
HD-ZIP Family
Species TF ID Description
PCP000041.1HD-ZIP family protein
PCP000042.1HD-ZIP family protein
PCP000095.1HD-ZIP family protein
PCP000172.1HD-ZIP family protein
PCP000834.1HD-ZIP family protein
PCP001880.1HD-ZIP family protein
PCP003293.1HD-ZIP family protein
PCP003314.1HD-ZIP family protein
PCP003470.1HD-ZIP family protein
PCP003786.1HD-ZIP family protein
PCP004009.1HD-ZIP family protein
PCP004056.1HD-ZIP family protein
PCP004632.1HD-ZIP family protein
PCP005404.1HD-ZIP family protein
PCP005466.1HD-ZIP family protein
PCP005667.1HD-ZIP family protein
PCP006727.1HD-ZIP family protein
PCP008264.1HD-ZIP family protein
PCP009532.1HD-ZIP family protein
PCP010912.1HD-ZIP family protein
PCP012211.1HD-ZIP family protein
PCP012946.1HD-ZIP family protein
PCP013974.1HD-ZIP family protein
PCP014697.1HD-ZIP family protein
PCP014783.1HD-ZIP family protein
PCP015511.1HD-ZIP family protein
PCP016376.1HD-ZIP family protein
PCP017419.1HD-ZIP family protein
PCP017886.1HD-ZIP family protein
PCP019418.1HD-ZIP family protein
PCP019945.1HD-ZIP family protein
PCP020549.1HD-ZIP family protein
PCP020983.1HD-ZIP family protein
PCP021017.1HD-ZIP family protein
PCP021052.1HD-ZIP family protein
PCP021696.1HD-ZIP family protein
PCP021920.1HD-ZIP family protein
PCP023302.1HD-ZIP family protein
PCP023467.1HD-ZIP family protein
PCP024589.1HD-ZIP family protein
PCP024738.1HD-ZIP family protein
PCP026141.1HD-ZIP family protein
PCP026730.1HD-ZIP family protein
PCP027574.1HD-ZIP family protein
PCP027959.1HD-ZIP family protein
PCP028035.1HD-ZIP family protein
PCP030407.1HD-ZIP family protein
PCP030669.1HD-ZIP family protein
PCP030679.1HD-ZIP family protein
PCP031026.1HD-ZIP family protein
PCP032242.1HD-ZIP family protein
PCP032243.1HD-ZIP family protein
PCP032825.1HD-ZIP family protein
PCP033132.1HD-ZIP family protein
PCP036288.1HD-ZIP family protein
PCP039324.1HD-ZIP family protein
PCP039815.1HD-ZIP family protein
PCP039816.1HD-ZIP family protein
PCP040000.1HD-ZIP family protein
PCP041966.1HD-ZIP family protein
PCP044707.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401