PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Oryza sativa f. spontanea
Species TF ID Description
ONIVA01G08650.1MIKC_MADS family protein
ONIVA01G08650.2MIKC_MADS family protein
ONIVA01G33710.1MIKC_MADS family protein
ONIVA01G44390.1MIKC_MADS family protein
ONIVA01G44610.1MIKC_MADS family protein
ONIVA01G47560.1MIKC_MADS family protein
ONIVA02G00370.1MIKC_MADS family protein
ONIVA02G00370.2MIKC_MADS family protein
ONIVA02G05710.1MIKC_MADS family protein
ONIVA02G05710.2MIKC_MADS family protein
ONIVA02G06550.1MIKC_MADS family protein
ONIVA02G24100.1MIKC_MADS family protein
ONIVA02G31130.1MIKC_MADS family protein
ONIVA02G34790.1MIKC_MADS family protein
ONIVA02G35910.1MIKC_MADS family protein
ONIVA03G01420.1MIKC_MADS family protein
ONIVA03G01420.2MIKC_MADS family protein
ONIVA03G01420.3MIKC_MADS family protein
ONIVA03G01420.4MIKC_MADS family protein
ONIVA03G01420.5MIKC_MADS family protein
ONIVA03G09190.1MIKC_MADS family protein
ONIVA03G35990.1MIKC_MADS family protein
ONIVA03G43670.1MIKC_MADS family protein
ONIVA04G05310.1MIKC_MADS family protein
ONIVA04G11980.1MIKC_MADS family protein
ONIVA04G12010.1MIKC_MADS family protein
ONIVA04G21940.1MIKC_MADS family protein
ONIVA04G21940.2MIKC_MADS family protein
ONIVA04G21940.3MIKC_MADS family protein
ONIVA04G21940.4MIKC_MADS family protein
ONIVA05G07370.1MIKC_MADS family protein
ONIVA05G07370.2MIKC_MADS family protein
ONIVA05G07370.3MIKC_MADS family protein
ONIVA05G07370.4MIKC_MADS family protein
ONIVA05G07370.5MIKC_MADS family protein
ONIVA05G07370.6MIKC_MADS family protein
ONIVA05G17790.1MIKC_MADS family protein
ONIVA06G05400.1MIKC_MADS family protein
ONIVA06G29820.1MIKC_MADS family protein
ONIVA07G20220.1MIKC_MADS family protein
ONIVA08G00920.1MIKC_MADS family protein
ONIVA08G00920.2MIKC_MADS family protein
ONIVA08G16700.1MIKC_MADS family protein
ONIVA08G16700.2MIKC_MADS family protein
ONIVA08G24560.1MIKC_MADS family protein
ONIVA08G24560.2MIKC_MADS family protein
ONIVA08G24560.3MIKC_MADS family protein
ONIVA08G24570.1MIKC_MADS family protein
ONIVA09G16870.1MIKC_MADS family protein
ONIVA10G18680.1MIKC_MADS family protein
ONIVA10G18680.2MIKC_MADS family protein
ONIVA12G05620.1MIKC_MADS family protein
ONIVA12G05640.1MIKC_MADS family protein
ONIVA12G05640.2MIKC_MADS family protein
ONIVA12G05640.3MIKC_MADS family protein
ONIVA12G05640.4MIKC_MADS family protein
ONIVA12G13220.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513