PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Olea europaea var. sylvestris
M-type_MADS Family
Species TF ID Description
Oeu002089.1M-type_MADS family protein
Oeu006607.1M-type_MADS family protein
Oeu009929.1M-type_MADS family protein
Oeu009933.1M-type_MADS family protein
Oeu010457.1M-type_MADS family protein
Oeu010545.1M-type_MADS family protein
Oeu010550.1M-type_MADS family protein
Oeu016647.1M-type_MADS family protein
Oeu016906.1M-type_MADS family protein
Oeu017584.1M-type_MADS family protein
Oeu017585.1M-type_MADS family protein
Oeu017586.1M-type_MADS family protein
Oeu017587.1M-type_MADS family protein
Oeu018600.1M-type_MADS family protein
Oeu019130.1M-type_MADS family protein
Oeu020889.1M-type_MADS family protein
Oeu022771.1M-type_MADS family protein
Oeu022772.1M-type_MADS family protein
Oeu023243.1M-type_MADS family protein
Oeu023403.1M-type_MADS family protein
Oeu024642.1M-type_MADS family protein
Oeu025302.1M-type_MADS family protein
Oeu026465.1M-type_MADS family protein
Oeu028405.1M-type_MADS family protein
Oeu029234.1M-type_MADS family protein
Oeu029235.1M-type_MADS family protein
Oeu029249.1M-type_MADS family protein
Oeu029488.1M-type_MADS family protein
Oeu030264.1M-type_MADS family protein
Oeu031750.4M-type_MADS family protein
Oeu032519.1M-type_MADS family protein
Oeu032521.1M-type_MADS family protein
Oeu033016.1M-type_MADS family protein
Oeu034504.1M-type_MADS family protein
Oeu037771.1M-type_MADS family protein
Oeu038578.1M-type_MADS family protein
Oeu039510.1M-type_MADS family protein
Oeu040891.2M-type_MADS family protein
Oeu041404.1M-type_MADS family protein
Oeu041553.1M-type_MADS family protein
Oeu042246.1M-type_MADS family protein
Oeu043001.1M-type_MADS family protein
Oeu043454.1M-type_MADS family protein
Oeu045757.1M-type_MADS family protein
Oeu046899.1M-type_MADS family protein
Oeu046900.1M-type_MADS family protein
Oeu048605.1M-type_MADS family protein
Oeu048608.1M-type_MADS family protein
Oeu049758.1M-type_MADS family protein
Oeu049759.1M-type_MADS family protein
Oeu049760.1M-type_MADS family protein
Oeu050185.1M-type_MADS family protein
Oeu051193.1M-type_MADS family protein
Oeu051266.1M-type_MADS family protein
Oeu051415.1M-type_MADS family protein
Oeu052267.1M-type_MADS family protein
Oeu052268.2M-type_MADS family protein
Oeu053261.1M-type_MADS family protein
Oeu055551.1M-type_MADS family protein
Oeu055558.1M-type_MADS family protein
Oeu055567.1M-type_MADS family protein
Oeu055568.1M-type_MADS family protein
Oeu055569.1M-type_MADS family protein
Oeu055578.1M-type_MADS family protein
Oeu058849.1M-type_MADS family protein
Oeu060675.1M-type_MADS family protein
Oeu061767.1M-type_MADS family protein
Oeu061769.1M-type_MADS family protein
Oeu061838.1M-type_MADS family protein
Oeu063533.1M-type_MADS family protein
Oeu064521.1M-type_MADS family protein
Oeu064524.1M-type_MADS family protein
Oeu064601.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513