PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Nicotiana attenuata
WRKY Family
Species TF ID Description
OIS95927WRKY family protein
OIS95973WRKY family protein
OIS96470WRKY family protein
OIS96711WRKY family protein
OIS96845WRKY family protein
OIS98026WRKY family protein
OIS99437WRKY family protein
OIS99656WRKY family protein
OIT00233WRKY family protein
OIT00332WRKY family protein
OIT00595WRKY family protein
OIT00756WRKY family protein
OIT00876WRKY family protein
OIT01281WRKY family protein
OIT01744WRKY family protein
OIT02130WRKY family protein
OIT02229WRKY family protein
OIT03302WRKY family protein
OIT03460WRKY family protein
OIT03551WRKY family protein
OIT05036WRKY family protein
OIT05142WRKY family protein
OIT06516WRKY family protein
OIT06532WRKY family protein
OIT06544WRKY family protein
OIT06607WRKY family protein
OIT06864WRKY family protein
OIT06926WRKY family protein
OIT07361WRKY family protein
OIT08032WRKY family protein
OIT08408WRKY family protein
OIT19199WRKY family protein
OIT20712WRKY family protein
OIT20713WRKY family protein
OIT21182WRKY family protein
OIT22093WRKY family protein
OIT22217WRKY family protein
OIT24261WRKY family protein
OIT25862WRKY family protein
OIT26510WRKY family protein
OIT26945WRKY family protein
OIT27204WRKY family protein
OIT27479WRKY family protein
OIT27582WRKY family protein
OIT27991WRKY family protein
OIT28812WRKY family protein
OIT28936WRKY family protein
OIT29321WRKY family protein
OIT29406WRKY family protein
OIT30401WRKY family protein
OIT30682WRKY family protein
OIT31789WRKY family protein
OIT33210WRKY family protein
OIT33212WRKY family protein
OIT33317WRKY family protein
OIT33968WRKY family protein
OIT34050WRKY family protein
OIT34213WRKY family protein
OIT34608WRKY family protein
OIT35457WRKY family protein
OIT36053WRKY family protein
OIT36547WRKY family protein
OIT36961WRKY family protein
OIT37288WRKY family protein
OIT37488WRKY family protein
OIT37599WRKY family protein
OIT37684WRKY family protein
OIT38536WRKY family protein
OIT38538WRKY family protein
OIT38728WRKY family protein
OIT38929WRKY family protein
OIT39097WRKY family protein
OIT39563WRKY family protein
OIT40460WRKY family protein
OIT40747WRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701