PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Nicotiana attenuata
ARF Family
Species TF ID Description
OIS98057ARF family protein
OIS99983ARF family protein
OIT02046ARF family protein
OIT02328ARF family protein
OIT03395ARF family protein
OIT04660ARF family protein
OIT06010ARF family protein
OIT07754ARF family protein
OIT19118ARF family protein
OIT21048ARF family protein
OIT24449ARF family protein
OIT25622ARF family protein
OIT26832ARF family protein
OIT27388ARF family protein
OIT29056ARF family protein
OIT29486ARF family protein
OIT29588ARF family protein
OIT29990ARF family protein
OIT30755ARF family protein
OIT36439ARF family protein
OIT36774ARF family protein
OIT37945ARF family protein
OIT39133ARF family protein
ARF Family Introduction

Auxin response factors (ARF) are transcription factors that regulate the expression of auxin response genes. ARFs bind with specificity to TGTCTC auxin response elements (AuxRE) in promoters of these genes and function in combination with Aux/IAA (auxin/indole acetic acid) repressors, which dimerize with ARF activators in an auxin-regulated manner.

Most ARFs consist of an amino-terminal DNA-binding domain (DBD), a middle region that functions as an activation domain (AD) or repression domain (RD), and a carboxy-terminal dimerization domain (CTD). The ARF DBD is classified as a plant-specific B3-type, but requires additional amino-terminal and carboxy-terminal amino acids for efficient in vitro binding to TGTCTC AuxREs.

The ARF ADs and RDs are located just carboxy-terminal to the DBDs and contain biased amino acid sequences. ARF ADs are enriched in glutamine along with serine and leucine residues, while ARF RDs are enriched in serine, proline, leucine and glycine residues.

Guilfoyle TJ, Hagen G.
Auxin response factors.
Curr Opin Plant Biol, 2007. 10(5): p. 453-60.
PMID: 17900969