PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Nicotiana attenuata
AP2 Family
Species TF ID Description
OIS96980AP2 family protein
OIS98895AP2 family protein
OIT01006AP2 family protein
OIT01511AP2 family protein
OIT02547AP2 family protein
OIT02800AP2 family protein
OIT03126AP2 family protein
OIT05313AP2 family protein
OIT06427AP2 family protein
OIT06567AP2 family protein
OIT06584AP2 family protein
OIT06609AP2 family protein
OIT06983AP2 family protein
OIT08632AP2 family protein
OIT19032AP2 family protein
OIT19435AP2 family protein
OIT21021AP2 family protein
OIT21289AP2 family protein
OIT21995AP2 family protein
OIT22547AP2 family protein
OIT28841AP2 family protein
OIT29347AP2 family protein
OIT30764AP2 family protein
OIT31440AP2 family protein
OIT35648AP2 family protein
OIT36841AP2 family protein
OIT36852AP2 family protein
OIT38055AP2 family protein
AP2 Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

Genes in the AP2 family have been shown to participate in the regulation of developmental processes, e.g. flower development, spikelet meristem determinacy, leaf epidermal cell identity, and embryo development.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444

Using an in vitro selection procedure, the DNA binding specificity of the two AP2 repeat containing protein ANT was found to be 5'-gCAC(A/G)N(A/T)TcCC(a/g)ANG(c/t)-3'. This consensus site is much longer than sites recognized by proteins containing a single AP2 repeat and neither AP2 repeat of ANT was alone capable of binding to the selected sequences, suggesting that both AP2 repeats make DNA contacts.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102