PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Macleaya cordata
HD-ZIP Family
Species TF ID Description
OUZ99599.1HD-ZIP family protein
OVA00317.1HD-ZIP family protein
OVA00325.1HD-ZIP family protein
OVA01767.1HD-ZIP family protein
OVA02876.1HD-ZIP family protein
OVA03238.1HD-ZIP family protein
OVA04549.1HD-ZIP family protein
OVA04665.1HD-ZIP family protein
OVA07605.1HD-ZIP family protein
OVA08558.1HD-ZIP family protein
OVA09051.1HD-ZIP family protein
OVA09079.1HD-ZIP family protein
OVA10133.1HD-ZIP family protein
OVA10576.1HD-ZIP family protein
OVA11125.1HD-ZIP family protein
OVA11224.1HD-ZIP family protein
OVA13031.1HD-ZIP family protein
OVA13081.1HD-ZIP family protein
OVA13324.1HD-ZIP family protein
OVA14140.1HD-ZIP family protein
OVA14390.1HD-ZIP family protein
OVA14562.1HD-ZIP family protein
OVA14765.1HD-ZIP family protein
OVA16071.1HD-ZIP family protein
OVA17883.1HD-ZIP family protein
OVA18075.1HD-ZIP family protein
OVA18663.1HD-ZIP family protein
OVA20248.1HD-ZIP family protein
OVA20332.1HD-ZIP family protein
OVA20898.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401