PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Momordica charantia
MIKC_MADS Family
Species TF ID Description
XP_022131257.1MIKC_MADS family protein
XP_022131258.1MIKC_MADS family protein
XP_022131259.1MIKC_MADS family protein
XP_022131965.1MIKC_MADS family protein
XP_022131973.1MIKC_MADS family protein
XP_022132007.1MIKC_MADS family protein
XP_022133196.1MIKC_MADS family protein
XP_022133337.1MIKC_MADS family protein
XP_022133338.1MIKC_MADS family protein
XP_022133339.1MIKC_MADS family protein
XP_022133340.1MIKC_MADS family protein
XP_022133342.1MIKC_MADS family protein
XP_022136271.1MIKC_MADS family protein
XP_022136666.1MIKC_MADS family protein
XP_022137440.1MIKC_MADS family protein
XP_022137566.1MIKC_MADS family protein
XP_022137567.1MIKC_MADS family protein
XP_022137568.1MIKC_MADS family protein
XP_022139885.1MIKC_MADS family protein
XP_022140853.1MIKC_MADS family protein
XP_022140854.1MIKC_MADS family protein
XP_022141193.1MIKC_MADS family protein
XP_022141961.1MIKC_MADS family protein
XP_022141962.1MIKC_MADS family protein
XP_022142063.1MIKC_MADS family protein
XP_022142064.1MIKC_MADS family protein
XP_022143898.1MIKC_MADS family protein
XP_022146242.1MIKC_MADS family protein
XP_022146643.1MIKC_MADS family protein
XP_022146644.1MIKC_MADS family protein
XP_022146645.1MIKC_MADS family protein
XP_022146646.1MIKC_MADS family protein
XP_022147398.1MIKC_MADS family protein
XP_022147399.1MIKC_MADS family protein
XP_022149183.1MIKC_MADS family protein
XP_022149184.1MIKC_MADS family protein
XP_022149185.1MIKC_MADS family protein
XP_022149232.1MIKC_MADS family protein
XP_022149592.1MIKC_MADS family protein
XP_022149989.1MIKC_MADS family protein
XP_022149991.1MIKC_MADS family protein
XP_022149992.1MIKC_MADS family protein
XP_022149997.1MIKC_MADS family protein
XP_022149998.1MIKC_MADS family protein
XP_022152219.1MIKC_MADS family protein
XP_022152220.1MIKC_MADS family protein
XP_022152602.1MIKC_MADS family protein
XP_022152603.1MIKC_MADS family protein
XP_022152604.1MIKC_MADS family protein
XP_022152605.1MIKC_MADS family protein
XP_022154226.1MIKC_MADS family protein
XP_022155022.1MIKC_MADS family protein
XP_022155032.1MIKC_MADS family protein
XP_022155415.1MIKC_MADS family protein
XP_022155416.1MIKC_MADS family protein
XP_022155417.1MIKC_MADS family protein
XP_022155454.1MIKC_MADS family protein
XP_022156217.1MIKC_MADS family protein
XP_022157959.1MIKC_MADS family protein
XP_022158021.1MIKC_MADS family protein
XP_022158088.1MIKC_MADS family protein
XP_022158157.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513