PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Ipomoea nil
MIKC_MADS Family
Species TF ID Description
XP_019149822.1MIKC_MADS family protein
XP_019151822.1MIKC_MADS family protein
XP_019152666.1MIKC_MADS family protein
XP_019152667.1MIKC_MADS family protein
XP_019153096.1MIKC_MADS family protein
XP_019154917.1MIKC_MADS family protein
XP_019154918.1MIKC_MADS family protein
XP_019155860.1MIKC_MADS family protein
XP_019155989.1MIKC_MADS family protein
XP_019156247.1MIKC_MADS family protein
XP_019156248.1MIKC_MADS family protein
XP_019156249.1MIKC_MADS family protein
XP_019157001.1MIKC_MADS family protein
XP_019157010.1MIKC_MADS family protein
XP_019157017.1MIKC_MADS family protein
XP_019159234.1MIKC_MADS family protein
XP_019159235.1MIKC_MADS family protein
XP_019159236.1MIKC_MADS family protein
XP_019159237.1MIKC_MADS family protein
XP_019159238.1MIKC_MADS family protein
XP_019163163.1MIKC_MADS family protein
XP_019163164.1MIKC_MADS family protein
XP_019163165.1MIKC_MADS family protein
XP_019165379.1MIKC_MADS family protein
XP_019165380.1MIKC_MADS family protein
XP_019166137.1MIKC_MADS family protein
XP_019166138.1MIKC_MADS family protein
XP_019166161.1MIKC_MADS family protein
XP_019166843.1MIKC_MADS family protein
XP_019166844.1MIKC_MADS family protein
XP_019167777.1MIKC_MADS family protein
XP_019167778.1MIKC_MADS family protein
XP_019169212.1MIKC_MADS family protein
XP_019169213.1MIKC_MADS family protein
XP_019169214.1MIKC_MADS family protein
XP_019169215.1MIKC_MADS family protein
XP_019169216.1MIKC_MADS family protein
XP_019169239.1MIKC_MADS family protein
XP_019169240.1MIKC_MADS family protein
XP_019169242.1MIKC_MADS family protein
XP_019172632.1MIKC_MADS family protein
XP_019172633.1MIKC_MADS family protein
XP_019172634.1MIKC_MADS family protein
XP_019172635.1MIKC_MADS family protein
XP_019172957.1MIKC_MADS family protein
XP_019172959.1MIKC_MADS family protein
XP_019172960.1MIKC_MADS family protein
XP_019172961.1MIKC_MADS family protein
XP_019172962.1MIKC_MADS family protein
XP_019172963.1MIKC_MADS family protein
XP_019172964.1MIKC_MADS family protein
XP_019172965.1MIKC_MADS family protein
XP_019172966.1MIKC_MADS family protein
XP_019172967.1MIKC_MADS family protein
XP_019172968.1MIKC_MADS family protein
XP_019172969.1MIKC_MADS family protein
XP_019172970.1MIKC_MADS family protein
XP_019173086.1MIKC_MADS family protein
XP_019173095.1MIKC_MADS family protein
XP_019173225.1MIKC_MADS family protein
XP_019173228.1MIKC_MADS family protein
XP_019175011.1MIKC_MADS family protein
XP_019175013.1MIKC_MADS family protein
XP_019175061.1MIKC_MADS family protein
XP_019175062.1MIKC_MADS family protein
XP_019175063.1MIKC_MADS family protein
XP_019175389.1MIKC_MADS family protein
XP_019175390.1MIKC_MADS family protein
XP_019176764.1MIKC_MADS family protein
XP_019176765.1MIKC_MADS family protein
XP_019176798.1MIKC_MADS family protein
XP_019176799.1MIKC_MADS family protein
XP_019176800.1MIKC_MADS family protein
XP_019180139.1MIKC_MADS family protein
XP_019180614.1MIKC_MADS family protein
XP_019180616.1MIKC_MADS family protein
XP_019180617.1MIKC_MADS family protein
XP_019180618.1MIKC_MADS family protein
XP_019182444.1MIKC_MADS family protein
XP_019182445.1MIKC_MADS family protein
XP_019184334.1MIKC_MADS family protein
XP_019185164.1MIKC_MADS family protein
XP_019185726.1MIKC_MADS family protein
XP_019185728.1MIKC_MADS family protein
XP_019185729.1MIKC_MADS family protein
XP_019186241.1MIKC_MADS family protein
XP_019189703.1MIKC_MADS family protein
XP_019189707.1MIKC_MADS family protein
XP_019189709.1MIKC_MADS family protein
XP_019189714.1MIKC_MADS family protein
XP_019192450.1MIKC_MADS family protein
XP_019192451.1MIKC_MADS family protein
XP_019192453.1MIKC_MADS family protein
XP_019192454.1MIKC_MADS family protein
XP_019192455.1MIKC_MADS family protein
XP_019192456.1MIKC_MADS family protein
XP_019192457.1MIKC_MADS family protein
XP_019192458.1MIKC_MADS family protein
XP_019194409.1MIKC_MADS family protein
XP_019194411.1MIKC_MADS family protein
XP_019199795.1MIKC_MADS family protein
XP_019199837.1MIKC_MADS family protein
XP_019199881.1MIKC_MADS family protein
XP_019199885.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513