PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Ipomoea nil
M-type_MADS Family
Species TF ID Description
XP_019151865.1M-type_MADS family protein
XP_019152624.1M-type_MADS family protein
XP_019152625.1M-type_MADS family protein
XP_019155349.1M-type_MADS family protein
XP_019155448.1M-type_MADS family protein
XP_019155484.1M-type_MADS family protein
XP_019155497.1M-type_MADS family protein
XP_019155546.1M-type_MADS family protein
XP_019155558.1M-type_MADS family protein
XP_019155579.1M-type_MADS family protein
XP_019155909.1M-type_MADS family protein
XP_019155933.1M-type_MADS family protein
XP_019157588.1M-type_MADS family protein
XP_019157591.1M-type_MADS family protein
XP_019157592.1M-type_MADS family protein
XP_019157738.1M-type_MADS family protein
XP_019160724.1M-type_MADS family protein
XP_019164507.1M-type_MADS family protein
XP_019165299.1M-type_MADS family protein
XP_019165300.1M-type_MADS family protein
XP_019167630.1M-type_MADS family protein
XP_019168806.1M-type_MADS family protein
XP_019169968.1M-type_MADS family protein
XP_019169980.1M-type_MADS family protein
XP_019170411.1M-type_MADS family protein
XP_019170462.1M-type_MADS family protein
XP_019170880.1M-type_MADS family protein
XP_019171191.1M-type_MADS family protein
XP_019171202.1M-type_MADS family protein
XP_019171499.1M-type_MADS family protein
XP_019176188.1M-type_MADS family protein
XP_019176892.1M-type_MADS family protein
XP_019179004.1M-type_MADS family protein
XP_019179005.1M-type_MADS family protein
XP_019179194.1M-type_MADS family protein
XP_019179195.1M-type_MADS family protein
XP_019179196.1M-type_MADS family protein
XP_019179197.1M-type_MADS family protein
XP_019182147.1M-type_MADS family protein
XP_019183831.1M-type_MADS family protein
XP_019183833.1M-type_MADS family protein
XP_019185048.1M-type_MADS family protein
XP_019185050.1M-type_MADS family protein
XP_019185051.1M-type_MADS family protein
XP_019185053.1M-type_MADS family protein
XP_019185054.1M-type_MADS family protein
XP_019185055.1M-type_MADS family protein
XP_019185056.1M-type_MADS family protein
XP_019185057.1M-type_MADS family protein
XP_019185059.1M-type_MADS family protein
XP_019185971.1M-type_MADS family protein
XP_019186570.1M-type_MADS family protein
XP_019189701.1M-type_MADS family protein
XP_019189897.1M-type_MADS family protein
XP_019189899.1M-type_MADS family protein
XP_019191069.1M-type_MADS family protein
XP_019191071.1M-type_MADS family protein
XP_019191276.1M-type_MADS family protein
XP_019193097.1M-type_MADS family protein
XP_019193122.1M-type_MADS family protein
XP_019193557.1M-type_MADS family protein
XP_019196307.1M-type_MADS family protein
XP_019196308.1M-type_MADS family protein
XP_019198284.1M-type_MADS family protein
XP_019198285.1M-type_MADS family protein
XP_019198286.1M-type_MADS family protein
XP_019198287.1M-type_MADS family protein
XP_019198288.1M-type_MADS family protein
XP_019200235.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513